Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice

Insulin resistance is associated with aging in mice and humans. We have previously shown that administration of recombinant GDF11 (rGDF11) to aged mice alters aging phenotypes in the brain, skeletal muscle, and heart. While the closely related protein GDF8 has a role in metabolism, limited data are...

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Detalles Bibliográficos
Autores principales: Walker, Ryan G., Barrandon, Ornella, Poggioli, Tommaso, Dagdeviren, Sezin, Carroll, Shannon H., Mills, Melanie J., Mendello, Kourtney R., Gomez, Yanet, Loffredo, Francesco S., Pancoast, James R., Macias-Trevino, Claudio, Marts, Colin, LeClair, Katherine B., Noh, Hye-Lim, Kim, Taekyoon, Banks, Alexander S., Kim, Jason K., Cohen, David E., Wagers, Amy J., Melton, Douglas A., Lee, Richard T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067781/
https://www.ncbi.nlm.nih.gov/pubmed/32165710
http://dx.doi.org/10.1038/s41598-020-61443-y

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