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Molecular principles of metastasis: a hallmark of cancer revisited

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths. Yet, it remains poorly understood. The continuous evolution of cancer biology research and the emergence of new paradigms in the study of metastasis have revealed some of the molecular underpin...

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Autores principales: Fares, Jawad, Fares, Mohamad Y., Khachfe, Hussein H., Salhab, Hamza A., Fares, Youssef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067809/
https://www.ncbi.nlm.nih.gov/pubmed/32296047
http://dx.doi.org/10.1038/s41392-020-0134-x
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author Fares, Jawad
Fares, Mohamad Y.
Khachfe, Hussein H.
Salhab, Hamza A.
Fares, Youssef
author_facet Fares, Jawad
Fares, Mohamad Y.
Khachfe, Hussein H.
Salhab, Hamza A.
Fares, Youssef
author_sort Fares, Jawad
collection PubMed
description Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths. Yet, it remains poorly understood. The continuous evolution of cancer biology research and the emergence of new paradigms in the study of metastasis have revealed some of the molecular underpinnings of this dissemination process. The invading tumor cell, on its way to the target site, interacts with other proteins and cells. Recognition of these interactions improved the understanding of some of the biological principles of the metastatic cell that govern its mobility and plasticity. Communication with the tumor microenvironment allows invading cancer cells to overcome stromal challenges, settle, and colonize. These characteristics of cancer cells are driven by genetic and epigenetic modifications within the tumor cell itself and its microenvironment. Establishing the biological mechanisms of the metastatic process is crucial in finding open therapeutic windows for successful interventions. In this review, the authors explore the recent advancements in the field of metastasis and highlight the latest insights that contribute to shaping this hallmark of cancer.
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spelling pubmed-70678092020-03-19 Molecular principles of metastasis: a hallmark of cancer revisited Fares, Jawad Fares, Mohamad Y. Khachfe, Hussein H. Salhab, Hamza A. Fares, Youssef Signal Transduct Target Ther Review Article Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths. Yet, it remains poorly understood. The continuous evolution of cancer biology research and the emergence of new paradigms in the study of metastasis have revealed some of the molecular underpinnings of this dissemination process. The invading tumor cell, on its way to the target site, interacts with other proteins and cells. Recognition of these interactions improved the understanding of some of the biological principles of the metastatic cell that govern its mobility and plasticity. Communication with the tumor microenvironment allows invading cancer cells to overcome stromal challenges, settle, and colonize. These characteristics of cancer cells are driven by genetic and epigenetic modifications within the tumor cell itself and its microenvironment. Establishing the biological mechanisms of the metastatic process is crucial in finding open therapeutic windows for successful interventions. In this review, the authors explore the recent advancements in the field of metastasis and highlight the latest insights that contribute to shaping this hallmark of cancer. Nature Publishing Group UK 2020-03-12 /pmc/articles/PMC7067809/ /pubmed/32296047 http://dx.doi.org/10.1038/s41392-020-0134-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Fares, Jawad
Fares, Mohamad Y.
Khachfe, Hussein H.
Salhab, Hamza A.
Fares, Youssef
Molecular principles of metastasis: a hallmark of cancer revisited
title Molecular principles of metastasis: a hallmark of cancer revisited
title_full Molecular principles of metastasis: a hallmark of cancer revisited
title_fullStr Molecular principles of metastasis: a hallmark of cancer revisited
title_full_unstemmed Molecular principles of metastasis: a hallmark of cancer revisited
title_short Molecular principles of metastasis: a hallmark of cancer revisited
title_sort molecular principles of metastasis: a hallmark of cancer revisited
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067809/
https://www.ncbi.nlm.nih.gov/pubmed/32296047
http://dx.doi.org/10.1038/s41392-020-0134-x
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