SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development

In several metazoans, the number of active replication origins in embryonic nuclei is higher than in somatic ones, ensuring rapid genome duplication during synchronous embryonic cell divisions. High replication origin density can be restored by somatic nuclear reprogramming. However, mechanisms unde...

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Detalles Bibliográficos
Autores principales: Falbo, Lucia, Raspelli, Erica, Romeo, Francesco, Fiorani, Simona, Pezzimenti, Federica, Casagrande, Francesca, Costa, Ilaria, Parazzoli, Dario, Costanzo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067836/
https://www.ncbi.nlm.nih.gov/pubmed/32165637
http://dx.doi.org/10.1038/s41467-020-15180-5

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