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Sex differences in proximal femur shape: findings from a population-based study in adolescents
Hip shape is an important determinant of hip osteoarthritis (OA), which occurs more commonly in women. However, it remains unclear to what extent differences in OA prevalence are attributed to sex differences in hip shape. Here, we explore sex differences in proximal femur shape in a cohort of adole...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067853/ https://www.ncbi.nlm.nih.gov/pubmed/32165724 http://dx.doi.org/10.1038/s41598-020-61653-4 |
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author | Frysz, Monika Gregory, Jennifer Aspden, Richard M. Paternoster, Lavinia Tobias, Jonathan H. |
author_facet | Frysz, Monika Gregory, Jennifer Aspden, Richard M. Paternoster, Lavinia Tobias, Jonathan H. |
author_sort | Frysz, Monika |
collection | PubMed |
description | Hip shape is an important determinant of hip osteoarthritis (OA), which occurs more commonly in women. However, it remains unclear to what extent differences in OA prevalence are attributed to sex differences in hip shape. Here, we explore sex differences in proximal femur shape in a cohort of adolescents. Hip morphology was quantified using hip DXA scans from the Avon Longitudinal Study of Parents and Children. Independent modes of variation (hip shape mode (HSM) scores) were generated for each image using an adult reference statistical shape model (N = 19,379). Linear regression was used to examine sex differences for the top ten HSMs, adjusting for age, height, lean and fat mass. Complete outcome and covariate data were available for 4,428 and 4,369 participants at ages 14 and 18 years, respectively. Several HSMs showed sex differences at both time points. The combined effect of sex on hip shape at age 14 reflected flatter femoral head and smaller lesser trochanter in females compared with males and, following adjustment for age and body size, these differences became more pronounced. At age 18, smaller lesser trochanter and femoral neck width (FNW) in females still remained although differences in femoral head, femoral shaft and FNW were largely attenuated following adjustment. Sexual dimorphism in proximal femur shape can be discerned in adolescence and early adulthood. Observed differences in proximal femur shape, particularly at age 14 were largely independent of body size, however to what extent differences in hip shape in early life play a role in predisposing to hip OA in later life remains to be determined. |
format | Online Article Text |
id | pubmed-7067853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70678532020-03-19 Sex differences in proximal femur shape: findings from a population-based study in adolescents Frysz, Monika Gregory, Jennifer Aspden, Richard M. Paternoster, Lavinia Tobias, Jonathan H. Sci Rep Article Hip shape is an important determinant of hip osteoarthritis (OA), which occurs more commonly in women. However, it remains unclear to what extent differences in OA prevalence are attributed to sex differences in hip shape. Here, we explore sex differences in proximal femur shape in a cohort of adolescents. Hip morphology was quantified using hip DXA scans from the Avon Longitudinal Study of Parents and Children. Independent modes of variation (hip shape mode (HSM) scores) were generated for each image using an adult reference statistical shape model (N = 19,379). Linear regression was used to examine sex differences for the top ten HSMs, adjusting for age, height, lean and fat mass. Complete outcome and covariate data were available for 4,428 and 4,369 participants at ages 14 and 18 years, respectively. Several HSMs showed sex differences at both time points. The combined effect of sex on hip shape at age 14 reflected flatter femoral head and smaller lesser trochanter in females compared with males and, following adjustment for age and body size, these differences became more pronounced. At age 18, smaller lesser trochanter and femoral neck width (FNW) in females still remained although differences in femoral head, femoral shaft and FNW were largely attenuated following adjustment. Sexual dimorphism in proximal femur shape can be discerned in adolescence and early adulthood. Observed differences in proximal femur shape, particularly at age 14 were largely independent of body size, however to what extent differences in hip shape in early life play a role in predisposing to hip OA in later life remains to be determined. Nature Publishing Group UK 2020-03-12 /pmc/articles/PMC7067853/ /pubmed/32165724 http://dx.doi.org/10.1038/s41598-020-61653-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Frysz, Monika Gregory, Jennifer Aspden, Richard M. Paternoster, Lavinia Tobias, Jonathan H. Sex differences in proximal femur shape: findings from a population-based study in adolescents |
title | Sex differences in proximal femur shape: findings from a population-based study in adolescents |
title_full | Sex differences in proximal femur shape: findings from a population-based study in adolescents |
title_fullStr | Sex differences in proximal femur shape: findings from a population-based study in adolescents |
title_full_unstemmed | Sex differences in proximal femur shape: findings from a population-based study in adolescents |
title_short | Sex differences in proximal femur shape: findings from a population-based study in adolescents |
title_sort | sex differences in proximal femur shape: findings from a population-based study in adolescents |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067853/ https://www.ncbi.nlm.nih.gov/pubmed/32165724 http://dx.doi.org/10.1038/s41598-020-61653-4 |
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