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Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners
Mindfulness and meditation techniques have proven successful for the reduction of stress and improvement in general health. In addition, meditation is linked to longevity and longer telomere length, a proposed biomarker of human aging. Interestingly, DNA methylation changes have been described at sp...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067861/ https://www.ncbi.nlm.nih.gov/pubmed/32165663 http://dx.doi.org/10.1038/s41598-020-61241-6 |
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author | Mendioroz, Maite Puebla-Guedea, Marta Montero-Marín, Jesús Urdánoz-Casado, Amaya Blanco-Luquin, Idoia Roldán, Miren Labarga, Alberto García-Campayo, Javier |
author_facet | Mendioroz, Maite Puebla-Guedea, Marta Montero-Marín, Jesús Urdánoz-Casado, Amaya Blanco-Luquin, Idoia Roldán, Miren Labarga, Alberto García-Campayo, Javier |
author_sort | Mendioroz, Maite |
collection | PubMed |
description | Mindfulness and meditation techniques have proven successful for the reduction of stress and improvement in general health. In addition, meditation is linked to longevity and longer telomere length, a proposed biomarker of human aging. Interestingly, DNA methylation changes have been described at specific subtelomeric regions in long-term meditators compared to controls. However, the molecular basis underlying these beneficial effects of meditation on human health still remains unclear. Here we show that DNA methylation levels, measured by the Infinium HumanMethylation450 BeadChip (Illumina) array, at specific subtelomeric regions containing GPR31 and SERPINB9 genes were associated with telomere length in long-term meditators with a strong statistical trend when correcting for multiple testing. Notably, age showed no association with telomere length in the group of long-term meditators. These results may suggest that long-term meditation could be related to epigenetic mechanisms, in particular gene-specific DNA methylation changes at distinct subtelomeric regions. |
format | Online Article Text |
id | pubmed-7067861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70678612020-03-22 Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners Mendioroz, Maite Puebla-Guedea, Marta Montero-Marín, Jesús Urdánoz-Casado, Amaya Blanco-Luquin, Idoia Roldán, Miren Labarga, Alberto García-Campayo, Javier Sci Rep Article Mindfulness and meditation techniques have proven successful for the reduction of stress and improvement in general health. In addition, meditation is linked to longevity and longer telomere length, a proposed biomarker of human aging. Interestingly, DNA methylation changes have been described at specific subtelomeric regions in long-term meditators compared to controls. However, the molecular basis underlying these beneficial effects of meditation on human health still remains unclear. Here we show that DNA methylation levels, measured by the Infinium HumanMethylation450 BeadChip (Illumina) array, at specific subtelomeric regions containing GPR31 and SERPINB9 genes were associated with telomere length in long-term meditators with a strong statistical trend when correcting for multiple testing. Notably, age showed no association with telomere length in the group of long-term meditators. These results may suggest that long-term meditation could be related to epigenetic mechanisms, in particular gene-specific DNA methylation changes at distinct subtelomeric regions. Nature Publishing Group UK 2020-03-12 /pmc/articles/PMC7067861/ /pubmed/32165663 http://dx.doi.org/10.1038/s41598-020-61241-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Mendioroz, Maite Puebla-Guedea, Marta Montero-Marín, Jesús Urdánoz-Casado, Amaya Blanco-Luquin, Idoia Roldán, Miren Labarga, Alberto García-Campayo, Javier Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners |
title | Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners |
title_full | Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners |
title_fullStr | Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners |
title_full_unstemmed | Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners |
title_short | Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners |
title_sort | telomere length correlates with subtelomeric dna methylation in long-term mindfulness practitioners |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067861/ https://www.ncbi.nlm.nih.gov/pubmed/32165663 http://dx.doi.org/10.1038/s41598-020-61241-6 |
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