Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

Macrophages have important protective functions during infection with herpes simplex virus type 1 (HSV-1). However, molecular mechanisms that restrict viral propagation and protect from severe disease are unclear. Here we show that macrophages take up HSV-1 via endocytosis and transport the virions...

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Detalles Bibliográficos
Autores principales: Lang, Judith, Bohn, Patrick, Bhat, Hilal, Jastrow, Holger, Walkenfort, Bernd, Cansiz, Feyza, Fink, Julian, Bauer, Michael, Olszewski, Dominik, Ramos-Nascimento, Ana, Duhan, Vikas, Friedrich, Sarah-Kim, Becker, Katrin Anne, Krawczyk, Adalbert, Edwards, Michael J., Burchert, Andreas, Huber, Magdalena, Friebus-Kardash, Justa, Göthert, Joachim R., Hardt, Cornelia, Probst, Hans Christian, Schumacher, Fabian, Köhrer, Karl, Kleuser, Burkhard, Babiychuk, Eduard B., Sodeik, Beate, Seibel, Jürgen, Greber, Urs F., Lang, Philipp A., Gulbins, Erich, Lang, Karl S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067866/
https://www.ncbi.nlm.nih.gov/pubmed/32165633
http://dx.doi.org/10.1038/s41467-020-15072-8

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