Combined inhibition of Notch and FLT3 produces synergistic cytotoxic effects in FLT3/ITD(+) acute myeloid leukemia

Internal tandem duplication (ITD) mutations of FMS-like tyrosine kinase-3 (FLT3) are the most frequent genetic alterations in acute myeloid leukemia (AML) and predict a poor prognosis. FLT3 tyrosine kinase inhibitors (TKIs) provide short-term clinical responses, but the long-term prognosis of FLT3/I...

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Detalles Bibliográficos
Autores principales: Li, Dan, Li, Tongjuan, Shang, Zhen, Zhao, Lei, Xu, Qian, Tan, Jiaqi, Qin, Yun, Zhang, Yuanyuan, Cao, Yang, Wang, Na, Huang, Liang, Zhu, Xiaojian, Zhou, Kuangguo, Chen, Liting, Li, Chunrui, Xie, Ting, Yang, Yi, Wang, Jue, Zhou, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067872/
https://www.ncbi.nlm.nih.gov/pubmed/32296014
http://dx.doi.org/10.1038/s41392-020-0108-z

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