Cargando…
Cocktail of Hyaluronic Acid and Human Amniotic Mesenchymal Cells Effectively Repairs Cartilage Injuries in Sodium Iodoacetate-Induced Osteoarthritis Rats
Osteoarthritis (OA) is one of the most common refractory degenerative articular cartilage diseases. Human amniotic mesenchymal cells (hAMSCs) have emerged as a promising stem cell source for cartilage repair, and hyaluronic acid (HA) has proven to be a versatile regulator for stem cell transplantati...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068044/ https://www.ncbi.nlm.nih.gov/pubmed/32211385 http://dx.doi.org/10.3389/fbioe.2020.00087 |
_version_ | 1783505497463193600 |
---|---|
author | Wang, Ai-Tong Zhang, Qing-Fang Wang, Nuo-Xin Yu, Chang-Yin Liu, Ru-Ming Luo, Yi Zhao, Yu-Jie Xiao, Jian-Hui |
author_facet | Wang, Ai-Tong Zhang, Qing-Fang Wang, Nuo-Xin Yu, Chang-Yin Liu, Ru-Ming Luo, Yi Zhao, Yu-Jie Xiao, Jian-Hui |
author_sort | Wang, Ai-Tong |
collection | PubMed |
description | Osteoarthritis (OA) is one of the most common refractory degenerative articular cartilage diseases. Human amniotic mesenchymal cells (hAMSCs) have emerged as a promising stem cell source for cartilage repair, and hyaluronic acid (HA) has proven to be a versatile regulator for stem cell transplantation. Herein, an effective and straightforward intra-articular injection therapy using a cocktail of hAMSCs and HA was developed to treat knee OA in a rat model. The injured cartilage was remarkably regenerated, yielding results comparable to normal cartilage levels after 56 days of treatment. Both hAMSCs and HA were indispensable organic components in this therapy, in which HA could synergistically enhance the effects of hAMSCs on cartilage repair. The regenerative mechanism was attributed to the fact that the addition of HA comprehensively enhances the activities of hAMSCs, including chondrogenic differentiation, proliferation, colonization, and regenerative modulation. This cocktail paves a new avenue for injection therapy to treat OA, holding the potential to realize rapid clinical translation. |
format | Online Article Text |
id | pubmed-7068044 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70680442020-03-24 Cocktail of Hyaluronic Acid and Human Amniotic Mesenchymal Cells Effectively Repairs Cartilage Injuries in Sodium Iodoacetate-Induced Osteoarthritis Rats Wang, Ai-Tong Zhang, Qing-Fang Wang, Nuo-Xin Yu, Chang-Yin Liu, Ru-Ming Luo, Yi Zhao, Yu-Jie Xiao, Jian-Hui Front Bioeng Biotechnol Bioengineering and Biotechnology Osteoarthritis (OA) is one of the most common refractory degenerative articular cartilage diseases. Human amniotic mesenchymal cells (hAMSCs) have emerged as a promising stem cell source for cartilage repair, and hyaluronic acid (HA) has proven to be a versatile regulator for stem cell transplantation. Herein, an effective and straightforward intra-articular injection therapy using a cocktail of hAMSCs and HA was developed to treat knee OA in a rat model. The injured cartilage was remarkably regenerated, yielding results comparable to normal cartilage levels after 56 days of treatment. Both hAMSCs and HA were indispensable organic components in this therapy, in which HA could synergistically enhance the effects of hAMSCs on cartilage repair. The regenerative mechanism was attributed to the fact that the addition of HA comprehensively enhances the activities of hAMSCs, including chondrogenic differentiation, proliferation, colonization, and regenerative modulation. This cocktail paves a new avenue for injection therapy to treat OA, holding the potential to realize rapid clinical translation. Frontiers Media S.A. 2020-03-06 /pmc/articles/PMC7068044/ /pubmed/32211385 http://dx.doi.org/10.3389/fbioe.2020.00087 Text en Copyright © 2020 Wang, Zhang, Wang, Yu, Liu, Luo, Zhao and Xiao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Wang, Ai-Tong Zhang, Qing-Fang Wang, Nuo-Xin Yu, Chang-Yin Liu, Ru-Ming Luo, Yi Zhao, Yu-Jie Xiao, Jian-Hui Cocktail of Hyaluronic Acid and Human Amniotic Mesenchymal Cells Effectively Repairs Cartilage Injuries in Sodium Iodoacetate-Induced Osteoarthritis Rats |
title | Cocktail of Hyaluronic Acid and Human Amniotic Mesenchymal Cells Effectively Repairs Cartilage Injuries in Sodium Iodoacetate-Induced Osteoarthritis Rats |
title_full | Cocktail of Hyaluronic Acid and Human Amniotic Mesenchymal Cells Effectively Repairs Cartilage Injuries in Sodium Iodoacetate-Induced Osteoarthritis Rats |
title_fullStr | Cocktail of Hyaluronic Acid and Human Amniotic Mesenchymal Cells Effectively Repairs Cartilage Injuries in Sodium Iodoacetate-Induced Osteoarthritis Rats |
title_full_unstemmed | Cocktail of Hyaluronic Acid and Human Amniotic Mesenchymal Cells Effectively Repairs Cartilage Injuries in Sodium Iodoacetate-Induced Osteoarthritis Rats |
title_short | Cocktail of Hyaluronic Acid and Human Amniotic Mesenchymal Cells Effectively Repairs Cartilage Injuries in Sodium Iodoacetate-Induced Osteoarthritis Rats |
title_sort | cocktail of hyaluronic acid and human amniotic mesenchymal cells effectively repairs cartilage injuries in sodium iodoacetate-induced osteoarthritis rats |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068044/ https://www.ncbi.nlm.nih.gov/pubmed/32211385 http://dx.doi.org/10.3389/fbioe.2020.00087 |
work_keys_str_mv | AT wangaitong cocktailofhyaluronicacidandhumanamnioticmesenchymalcellseffectivelyrepairscartilageinjuriesinsodiumiodoacetateinducedosteoarthritisrats AT zhangqingfang cocktailofhyaluronicacidandhumanamnioticmesenchymalcellseffectivelyrepairscartilageinjuriesinsodiumiodoacetateinducedosteoarthritisrats AT wangnuoxin cocktailofhyaluronicacidandhumanamnioticmesenchymalcellseffectivelyrepairscartilageinjuriesinsodiumiodoacetateinducedosteoarthritisrats AT yuchangyin cocktailofhyaluronicacidandhumanamnioticmesenchymalcellseffectivelyrepairscartilageinjuriesinsodiumiodoacetateinducedosteoarthritisrats AT liuruming cocktailofhyaluronicacidandhumanamnioticmesenchymalcellseffectivelyrepairscartilageinjuriesinsodiumiodoacetateinducedosteoarthritisrats AT luoyi cocktailofhyaluronicacidandhumanamnioticmesenchymalcellseffectivelyrepairscartilageinjuriesinsodiumiodoacetateinducedosteoarthritisrats AT zhaoyujie cocktailofhyaluronicacidandhumanamnioticmesenchymalcellseffectivelyrepairscartilageinjuriesinsodiumiodoacetateinducedosteoarthritisrats AT xiaojianhui cocktailofhyaluronicacidandhumanamnioticmesenchymalcellseffectivelyrepairscartilageinjuriesinsodiumiodoacetateinducedosteoarthritisrats |