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Delayed response to proton beam treatment of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has become one of the leading causes of cancer death worldwide. There has been anecdotal report regarding the effectiveness of proton beam treatment for HCC. In this pre-clinical investigation, the woodchuck model of viral hepatitis infection-induced HCC was used for p...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Institute of Radiology.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068085/ https://www.ncbi.nlm.nih.gov/pubmed/32201597 http://dx.doi.org/10.1259/bjrcr.20180125 |
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author | Cheng, Chee-Wai Machtay, Mitchell Dorth, Jennifer Sergeeva, Olga Xia, Hangsheng manaspon, chawan wu, Hanping Iyer, Renuka Sexton, Sandra Xin, Wei Exner, Agata A Lee, Zhenghong |
author_facet | Cheng, Chee-Wai Machtay, Mitchell Dorth, Jennifer Sergeeva, Olga Xia, Hangsheng manaspon, chawan wu, Hanping Iyer, Renuka Sexton, Sandra Xin, Wei Exner, Agata A Lee, Zhenghong |
author_sort | Cheng, Chee-Wai |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) has become one of the leading causes of cancer death worldwide. There has been anecdotal report regarding the effectiveness of proton beam treatment for HCC. In this pre-clinical investigation, the woodchuck model of viral hepatitis infection-induced HCC was used for proton beam treatment experiment. The radiopaque fiducial markers that are biodegradable were injected around the tumor under ultrasound guidance to facilitate positioning in sequential treatments. An α cradle mode was used to ensure reproducibility of animal positioning on the treatment couch. A CT scan was performed first for contouring by a radiation oncologist. The CT data set with contours was then exported for dose planning. Three fractionations, each 750 CcGyE, were applied every other day with a Mevion S250 passive scattering proton therapy system. Multiphase contrast-enhanced CT scans were performed after the treatment and at later times for follow-ups. 3 weeks post-treatment, shrinking of the HCC nodule was detected and constituted to a partial response (30% reduction along the long axis). By week nine after treatment, the nodule disappeared during the arterial phase of multiphase contrast-enhanced CT scan. Pathological evaluation corroborated with this imaging response. A delayed, but complete imaging response to proton beam treatment applied to HCC was achieved with this unique and clinically relevant animal model of HCC. |
format | Online Article Text |
id | pubmed-7068085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The British Institute of Radiology. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70680852020-03-20 Delayed response to proton beam treatment of hepatocellular carcinoma Cheng, Chee-Wai Machtay, Mitchell Dorth, Jennifer Sergeeva, Olga Xia, Hangsheng manaspon, chawan wu, Hanping Iyer, Renuka Sexton, Sandra Xin, Wei Exner, Agata A Lee, Zhenghong BJR Case Rep Case Report Hepatocellular carcinoma (HCC) has become one of the leading causes of cancer death worldwide. There has been anecdotal report regarding the effectiveness of proton beam treatment for HCC. In this pre-clinical investigation, the woodchuck model of viral hepatitis infection-induced HCC was used for proton beam treatment experiment. The radiopaque fiducial markers that are biodegradable were injected around the tumor under ultrasound guidance to facilitate positioning in sequential treatments. An α cradle mode was used to ensure reproducibility of animal positioning on the treatment couch. A CT scan was performed first for contouring by a radiation oncologist. The CT data set with contours was then exported for dose planning. Three fractionations, each 750 CcGyE, were applied every other day with a Mevion S250 passive scattering proton therapy system. Multiphase contrast-enhanced CT scans were performed after the treatment and at later times for follow-ups. 3 weeks post-treatment, shrinking of the HCC nodule was detected and constituted to a partial response (30% reduction along the long axis). By week nine after treatment, the nodule disappeared during the arterial phase of multiphase contrast-enhanced CT scan. Pathological evaluation corroborated with this imaging response. A delayed, but complete imaging response to proton beam treatment applied to HCC was achieved with this unique and clinically relevant animal model of HCC. The British Institute of Radiology. 2020-02-12 /pmc/articles/PMC7068085/ /pubmed/32201597 http://dx.doi.org/10.1259/bjrcr.20180125 Text en © 2020 The Authors. Published by the British Institute of Radiology This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Case Report Cheng, Chee-Wai Machtay, Mitchell Dorth, Jennifer Sergeeva, Olga Xia, Hangsheng manaspon, chawan wu, Hanping Iyer, Renuka Sexton, Sandra Xin, Wei Exner, Agata A Lee, Zhenghong Delayed response to proton beam treatment of hepatocellular carcinoma |
title | Delayed response to proton beam treatment of hepatocellular carcinoma |
title_full | Delayed response to proton beam treatment of hepatocellular carcinoma |
title_fullStr | Delayed response to proton beam treatment of hepatocellular carcinoma |
title_full_unstemmed | Delayed response to proton beam treatment of hepatocellular carcinoma |
title_short | Delayed response to proton beam treatment of hepatocellular carcinoma |
title_sort | delayed response to proton beam treatment of hepatocellular carcinoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068085/ https://www.ncbi.nlm.nih.gov/pubmed/32201597 http://dx.doi.org/10.1259/bjrcr.20180125 |
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