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A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis
NRF2 is a master regulator of cellular anti-oxidant and anti-inflammatory responses, and strategies to augment NRF2-dependent responses may beneficial in many diseases. Basal NRF2 protein level is constrained by constitutive KEAP1-mediated degradation, but in the presence of electrophiles, NRF2 ubiq...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068124/ https://www.ncbi.nlm.nih.gov/pubmed/32171724 http://dx.doi.org/10.1016/j.redox.2020.101485 |