TLR9 Polymorphisms Might Contribute to the Ethnicity Bias for EBV-Infected Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is endemic in some ethnic groups. The association of NPC with the Epstein-Barr virus (EBV) is firmly established; however, the mechanism is still unclear. TLR9 is well known for its essential role in viral pathogen r...

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Detalles Bibliográficos
Autores principales: Roy Chattopadhyay, Nabanita, Chatterjee, Koustav, Tiwari, Nikhil, Chakrabarti, Sudipta, Sahu, Sushil Kumar, Deb Roy, Sankar, Ghosh, Arijit, Reddy, R. Rajendra, Das, Piyanki, Mal, Sudipa, Karnar, Basab Bijay, Das, Ashok Kumar, Tsering, Sam, Riba, Komri, puii, Zoreng, Zomawia, Eric, Singh, Y. Indibar, Suryawanshi, Amol Ratnakar, Kumar, Abhishek, Ganguly, Dipyaman, Goswami, Chandan, Choudhuri, Tathagata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068130/
https://www.ncbi.nlm.nih.gov/pubmed/32179470
http://dx.doi.org/10.1016/j.isci.2020.100937
Descripción
Sumario:Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is endemic in some ethnic groups. The association of NPC with the Epstein-Barr virus (EBV) is firmly established; however, the mechanism is still unclear. TLR9 is well known for its essential role in viral pathogen recognition and activation of innate immunity. Here, we report a set of TLR9 polymorphisms in the TIR-2 domain of the TLR9 protein collected from the EBV-infected NPC samples from northeast Indian populations sharing the aforesaid ethnicity. The occurrence of mutations is significantly high in these samples as we found a p value of <0.0001 at a significance level of 0.05. These might play an important role for the lack of function of TLR9 and thus for the higher occurrence of EBV-mediated NPC in such ethnic groups.

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