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Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade

The current study investigated the efficacy of podoplanin expression in tumor budding cells as a predictor of neck lymph node metastasis (NLM) in patients with tongue squamous cell carcinoma (SCC) of low tumor budding grade (TBG). A total of 99 patients with early T-stage tongue SCC of any clinical...

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Autores principales: Hamada, Mei, Ebihara, Yasuhiro, Nagata, Koji, Yano, Mitsutake, Kogashiwa, Yasunao, Nakahira, Mitsuhiko, Sugasawa, Masashi, Nagatsuka, Hitoshi, Yasuda, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068445/
https://www.ncbi.nlm.nih.gov/pubmed/32218810
http://dx.doi.org/10.3892/ol.2020.11358
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author Hamada, Mei
Ebihara, Yasuhiro
Nagata, Koji
Yano, Mitsutake
Kogashiwa, Yasunao
Nakahira, Mitsuhiko
Sugasawa, Masashi
Nagatsuka, Hitoshi
Yasuda, Masanori
author_facet Hamada, Mei
Ebihara, Yasuhiro
Nagata, Koji
Yano, Mitsutake
Kogashiwa, Yasunao
Nakahira, Mitsuhiko
Sugasawa, Masashi
Nagatsuka, Hitoshi
Yasuda, Masanori
author_sort Hamada, Mei
collection PubMed
description The current study investigated the efficacy of podoplanin expression in tumor budding cells as a predictor of neck lymph node metastasis (NLM) in patients with tongue squamous cell carcinoma (SCC) of low tumor budding grade (TBG). A total of 99 patients with early T-stage tongue SCC of any clinical N status who received the initial curative treatment were enrolled. The association between podoplanin expression and NLM was immunohistochemically analyzed, with a focus on tongue SCC with low TBG. The disease-specific survival (DSS) rate was 77% at 5 years, and a significant difference was observed between the NLM-positive and NLM-negative groups, and between the low (n=77) and high (n=22) TBG groups. In the low TBG group, there was a significant difference in DSS between the NLM-positive and NLM-negative groups. The multivariate analysis showed that lymphatic vessel invasion (ly) [odds ratio (OR)=11.5, 95% confidence interval (CI): 1.50–87.6; P=0.02] and podoplanin expression (OR=7.07, 95% CI: 1.80–27.7; P=0.005) were significantly correlated with NLM. Furthermore, negative predictive values (NPV) of ly and podoplanin expression for NLM were 75% and 88%, respectively. Considering the balance of stratification case number adding to ratio, NLM-negative prediction by podoplanin was more significant than that by ly for the low TBG group. The results of the present study demonstrated that podoplanin expression in tumor budding is an independent and efficient predictor of NLM in the tongue SCC with low TBG. The low TBG and podoplanin-negative cases may be candidates for the wait and watch policy, therefore, reducing inappropriate elective neck lymph node dissections.
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spelling pubmed-70684452020-03-26 Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade Hamada, Mei Ebihara, Yasuhiro Nagata, Koji Yano, Mitsutake Kogashiwa, Yasunao Nakahira, Mitsuhiko Sugasawa, Masashi Nagatsuka, Hitoshi Yasuda, Masanori Oncol Lett Articles The current study investigated the efficacy of podoplanin expression in tumor budding cells as a predictor of neck lymph node metastasis (NLM) in patients with tongue squamous cell carcinoma (SCC) of low tumor budding grade (TBG). A total of 99 patients with early T-stage tongue SCC of any clinical N status who received the initial curative treatment were enrolled. The association between podoplanin expression and NLM was immunohistochemically analyzed, with a focus on tongue SCC with low TBG. The disease-specific survival (DSS) rate was 77% at 5 years, and a significant difference was observed between the NLM-positive and NLM-negative groups, and between the low (n=77) and high (n=22) TBG groups. In the low TBG group, there was a significant difference in DSS between the NLM-positive and NLM-negative groups. The multivariate analysis showed that lymphatic vessel invasion (ly) [odds ratio (OR)=11.5, 95% confidence interval (CI): 1.50–87.6; P=0.02] and podoplanin expression (OR=7.07, 95% CI: 1.80–27.7; P=0.005) were significantly correlated with NLM. Furthermore, negative predictive values (NPV) of ly and podoplanin expression for NLM were 75% and 88%, respectively. Considering the balance of stratification case number adding to ratio, NLM-negative prediction by podoplanin was more significant than that by ly for the low TBG group. The results of the present study demonstrated that podoplanin expression in tumor budding is an independent and efficient predictor of NLM in the tongue SCC with low TBG. The low TBG and podoplanin-negative cases may be candidates for the wait and watch policy, therefore, reducing inappropriate elective neck lymph node dissections. D.A. Spandidos 2020-04 2020-01-29 /pmc/articles/PMC7068445/ /pubmed/32218810 http://dx.doi.org/10.3892/ol.2020.11358 Text en Copyright: © Hamada et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Hamada, Mei
Ebihara, Yasuhiro
Nagata, Koji
Yano, Mitsutake
Kogashiwa, Yasunao
Nakahira, Mitsuhiko
Sugasawa, Masashi
Nagatsuka, Hitoshi
Yasuda, Masanori
Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade
title Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade
title_full Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade
title_fullStr Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade
title_full_unstemmed Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade
title_short Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade
title_sort podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068445/
https://www.ncbi.nlm.nih.gov/pubmed/32218810
http://dx.doi.org/10.3892/ol.2020.11358
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