Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways

Large-conductance and Ca(2+)-activated K(+) (BK) channels are expressed in human hepatic stellate cells (HSCs), where they have roles in normal hepatic microcirculation, as well as in portal hypertension in liver cirrhosis through the regulation of contractility in activated HSCs. Nevertheless, whet...

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Detalles Bibliográficos
Autores principales: Yang, Linli, Han, Bo, Zhang, Man, Wang, Ya-Hui, Tao, Kun, Zhu, Michael X., He, Kunyan, Zhang, Zhi-Gang, Hou, Shangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068464/
https://www.ncbi.nlm.nih.gov/pubmed/32210801
http://dx.doi.org/10.3389/fphar.2020.00165

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