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Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature

Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in adults. It occurs only occasionally in oral soft tissues, and knowledge about its characteristics is based on a limited number of cases reported in the literature. Malignant fibrous histiocytoma belongs to the group of...

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Autores principales: Zhurakivska, Khrystyna, Troiano, Giuseppe, Montella, Marco, Lo Muzio, Lorenzo, Fiorillo, Luca, Cervino, Gabriele, Cicciù, Marco, D’Amico, Cesare, Rullo, Rosario, Laino, Gregorio, Di Stasio, Dario, Laino, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068479/
https://www.ncbi.nlm.nih.gov/pubmed/32102165
http://dx.doi.org/10.3390/ijerph17041426
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author Zhurakivska, Khrystyna
Troiano, Giuseppe
Montella, Marco
Lo Muzio, Lorenzo
Fiorillo, Luca
Cervino, Gabriele
Cicciù, Marco
D’Amico, Cesare
Rullo, Rosario
Laino, Gregorio
Di Stasio, Dario
Laino, Luigi
author_facet Zhurakivska, Khrystyna
Troiano, Giuseppe
Montella, Marco
Lo Muzio, Lorenzo
Fiorillo, Luca
Cervino, Gabriele
Cicciù, Marco
D’Amico, Cesare
Rullo, Rosario
Laino, Gregorio
Di Stasio, Dario
Laino, Luigi
author_sort Zhurakivska, Khrystyna
collection PubMed
description Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in adults. It occurs only occasionally in oral soft tissues, and knowledge about its characteristics is based on a limited number of cases reported in the literature. Malignant fibrous histiocytoma belongs to the group of soft tissue sarcomas and makes up less than 10% of soft tissue sarcomas. For therapeutic purposes, complete exeresis of the lesion (macroscopic and microscopic) is performed because they have frequent recurrences. As for complementary therapy in addition to surgery, neither radiotherapy nor chemotherapy have been shown to reduce the risk of death related to the disease. Often patients complain of a swelling that grows in a short period of time. It is quite common for patients to report trauma in the area, which is not the cause, but rather the event that allows diagnosis. The mass usually does not cause pain unless it compresses an adjacent nerve structure. The aim of this study is to systematically review the scientific literature in order to identify the most recent studies concerning malignant fibrous histiocytomas localized in oral soft tissues and report their main data. The main outcomes of this study concern the immunohistochemical, molecular, and clinical aspects of this pathology. A systematic review of articles in the electronic databases pubmed, Scopus, and Web of Science was performed. After the selection process, 11 studies met the inclusion criteria and were included in the review. The mean age of the patients was 50.8 years old. The lesions affected various parts of the oral cavity, showing predominantly storiform–pleomorphic patterns. All cases except one were treated with surgical resection and radiation therapy. Although some data emerged from this review, they remain limited to a few case reports. Further studies are necessary in order to standardize the approach to patients affected by oral malignant fibrous histiocytoma (MFH).
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spelling pubmed-70684792020-03-19 Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature Zhurakivska, Khrystyna Troiano, Giuseppe Montella, Marco Lo Muzio, Lorenzo Fiorillo, Luca Cervino, Gabriele Cicciù, Marco D’Amico, Cesare Rullo, Rosario Laino, Gregorio Di Stasio, Dario Laino, Luigi Int J Environ Res Public Health Review Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in adults. It occurs only occasionally in oral soft tissues, and knowledge about its characteristics is based on a limited number of cases reported in the literature. Malignant fibrous histiocytoma belongs to the group of soft tissue sarcomas and makes up less than 10% of soft tissue sarcomas. For therapeutic purposes, complete exeresis of the lesion (macroscopic and microscopic) is performed because they have frequent recurrences. As for complementary therapy in addition to surgery, neither radiotherapy nor chemotherapy have been shown to reduce the risk of death related to the disease. Often patients complain of a swelling that grows in a short period of time. It is quite common for patients to report trauma in the area, which is not the cause, but rather the event that allows diagnosis. The mass usually does not cause pain unless it compresses an adjacent nerve structure. The aim of this study is to systematically review the scientific literature in order to identify the most recent studies concerning malignant fibrous histiocytomas localized in oral soft tissues and report their main data. The main outcomes of this study concern the immunohistochemical, molecular, and clinical aspects of this pathology. A systematic review of articles in the electronic databases pubmed, Scopus, and Web of Science was performed. After the selection process, 11 studies met the inclusion criteria and were included in the review. The mean age of the patients was 50.8 years old. The lesions affected various parts of the oral cavity, showing predominantly storiform–pleomorphic patterns. All cases except one were treated with surgical resection and radiation therapy. Although some data emerged from this review, they remain limited to a few case reports. Further studies are necessary in order to standardize the approach to patients affected by oral malignant fibrous histiocytoma (MFH). MDPI 2020-02-23 2020-02 /pmc/articles/PMC7068479/ /pubmed/32102165 http://dx.doi.org/10.3390/ijerph17041426 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhurakivska, Khrystyna
Troiano, Giuseppe
Montella, Marco
Lo Muzio, Lorenzo
Fiorillo, Luca
Cervino, Gabriele
Cicciù, Marco
D’Amico, Cesare
Rullo, Rosario
Laino, Gregorio
Di Stasio, Dario
Laino, Luigi
Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature
title Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature
title_full Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature
title_fullStr Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature
title_full_unstemmed Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature
title_short Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature
title_sort oral health and molecular aspects of malignant fibrous histiocytoma patients: a systematic review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068479/
https://www.ncbi.nlm.nih.gov/pubmed/32102165
http://dx.doi.org/10.3390/ijerph17041426
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