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Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies

Tauopathies are a disease group characterized by either pathological accumulation or release of fragments of hyperphosphorylated tau proteins originating from the central nervous system. The tau hypotheses of Parkinson’s and Alzheimer’s diseases contain a clinically diverse spectrum of tauopathies....

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Autores principales: Aaseth, Jan, Buha, Aleksandra, Wallace, David R., Bjørklund, Geir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068520/
https://www.ncbi.nlm.nih.gov/pubmed/32079163
http://dx.doi.org/10.3390/ijerph17041269
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author Aaseth, Jan
Buha, Aleksandra
Wallace, David R.
Bjørklund, Geir
author_facet Aaseth, Jan
Buha, Aleksandra
Wallace, David R.
Bjørklund, Geir
author_sort Aaseth, Jan
collection PubMed
description Tauopathies are a disease group characterized by either pathological accumulation or release of fragments of hyperphosphorylated tau proteins originating from the central nervous system. The tau hypotheses of Parkinson’s and Alzheimer’s diseases contain a clinically diverse spectrum of tauopathies. Studies of case records of various tauopathies may reveal clinical phenotype characteristics of the disease. In addition, improved understanding of different tauopathies would disclose environmental factors, such as xenobiotics and trace metals, that can precipitate or modify the progression of the disorder. Important for diagnostics and monitoring of these disorders is a further development of adequate biomarkers, including refined neuroimaging, or proteomics. Our goal is to provide an in-depth review of the current literature regarding the pathophysiological roles of tau proteins and the pathogenic factors leading to various tauopathies, with the perspective of future advances in potential therapeutic strategies.
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spelling pubmed-70685202020-03-19 Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies Aaseth, Jan Buha, Aleksandra Wallace, David R. Bjørklund, Geir Int J Environ Res Public Health Review Tauopathies are a disease group characterized by either pathological accumulation or release of fragments of hyperphosphorylated tau proteins originating from the central nervous system. The tau hypotheses of Parkinson’s and Alzheimer’s diseases contain a clinically diverse spectrum of tauopathies. Studies of case records of various tauopathies may reveal clinical phenotype characteristics of the disease. In addition, improved understanding of different tauopathies would disclose environmental factors, such as xenobiotics and trace metals, that can precipitate or modify the progression of the disorder. Important for diagnostics and monitoring of these disorders is a further development of adequate biomarkers, including refined neuroimaging, or proteomics. Our goal is to provide an in-depth review of the current literature regarding the pathophysiological roles of tau proteins and the pathogenic factors leading to various tauopathies, with the perspective of future advances in potential therapeutic strategies. MDPI 2020-02-17 2020-02 /pmc/articles/PMC7068520/ /pubmed/32079163 http://dx.doi.org/10.3390/ijerph17041269 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aaseth, Jan
Buha, Aleksandra
Wallace, David R.
Bjørklund, Geir
Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies
title Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies
title_full Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies
title_fullStr Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies
title_full_unstemmed Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies
title_short Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies
title_sort xenobiotics, trace metals and genetics in the pathogenesis of tauopathies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068520/
https://www.ncbi.nlm.nih.gov/pubmed/32079163
http://dx.doi.org/10.3390/ijerph17041269
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