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Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies
Tauopathies are a disease group characterized by either pathological accumulation or release of fragments of hyperphosphorylated tau proteins originating from the central nervous system. The tau hypotheses of Parkinson’s and Alzheimer’s diseases contain a clinically diverse spectrum of tauopathies....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068520/ https://www.ncbi.nlm.nih.gov/pubmed/32079163 http://dx.doi.org/10.3390/ijerph17041269 |
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author | Aaseth, Jan Buha, Aleksandra Wallace, David R. Bjørklund, Geir |
author_facet | Aaseth, Jan Buha, Aleksandra Wallace, David R. Bjørklund, Geir |
author_sort | Aaseth, Jan |
collection | PubMed |
description | Tauopathies are a disease group characterized by either pathological accumulation or release of fragments of hyperphosphorylated tau proteins originating from the central nervous system. The tau hypotheses of Parkinson’s and Alzheimer’s diseases contain a clinically diverse spectrum of tauopathies. Studies of case records of various tauopathies may reveal clinical phenotype characteristics of the disease. In addition, improved understanding of different tauopathies would disclose environmental factors, such as xenobiotics and trace metals, that can precipitate or modify the progression of the disorder. Important for diagnostics and monitoring of these disorders is a further development of adequate biomarkers, including refined neuroimaging, or proteomics. Our goal is to provide an in-depth review of the current literature regarding the pathophysiological roles of tau proteins and the pathogenic factors leading to various tauopathies, with the perspective of future advances in potential therapeutic strategies. |
format | Online Article Text |
id | pubmed-7068520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70685202020-03-19 Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies Aaseth, Jan Buha, Aleksandra Wallace, David R. Bjørklund, Geir Int J Environ Res Public Health Review Tauopathies are a disease group characterized by either pathological accumulation or release of fragments of hyperphosphorylated tau proteins originating from the central nervous system. The tau hypotheses of Parkinson’s and Alzheimer’s diseases contain a clinically diverse spectrum of tauopathies. Studies of case records of various tauopathies may reveal clinical phenotype characteristics of the disease. In addition, improved understanding of different tauopathies would disclose environmental factors, such as xenobiotics and trace metals, that can precipitate or modify the progression of the disorder. Important for diagnostics and monitoring of these disorders is a further development of adequate biomarkers, including refined neuroimaging, or proteomics. Our goal is to provide an in-depth review of the current literature regarding the pathophysiological roles of tau proteins and the pathogenic factors leading to various tauopathies, with the perspective of future advances in potential therapeutic strategies. MDPI 2020-02-17 2020-02 /pmc/articles/PMC7068520/ /pubmed/32079163 http://dx.doi.org/10.3390/ijerph17041269 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Aaseth, Jan Buha, Aleksandra Wallace, David R. Bjørklund, Geir Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies |
title | Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies |
title_full | Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies |
title_fullStr | Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies |
title_full_unstemmed | Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies |
title_short | Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies |
title_sort | xenobiotics, trace metals and genetics in the pathogenesis of tauopathies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068520/ https://www.ncbi.nlm.nih.gov/pubmed/32079163 http://dx.doi.org/10.3390/ijerph17041269 |
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