Cancer Stem Cells: A Potential Breakthrough in HCC-Targeted Therapy

Cancer stem cells (CSCs) are subpopulations of cells with stem cell characteristics that produce both cancerous and non-tumorigenic cells in tumor tissues. The literature reports that CSCs are closely related to the development of hepatocellular carcinoma (HCC) and promote the malignant features of...

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Autores principales: Wu, Yafei, Zhang, Jigang, Zhang, Xue, Zhou, Heming, Liu, Gaolin, Li, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068598/
https://www.ncbi.nlm.nih.gov/pubmed/32210805
http://dx.doi.org/10.3389/fphar.2020.00198
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author Wu, Yafei
Zhang, Jigang
Zhang, Xue
Zhou, Heming
Liu, Gaolin
Li, Qin
author_facet Wu, Yafei
Zhang, Jigang
Zhang, Xue
Zhou, Heming
Liu, Gaolin
Li, Qin
author_sort Wu, Yafei
collection PubMed
description Cancer stem cells (CSCs) are subpopulations of cells with stem cell characteristics that produce both cancerous and non-tumorigenic cells in tumor tissues. The literature reports that CSCs are closely related to the development of hepatocellular carcinoma (HCC) and promote the malignant features of HCC such as high invasion, drug resistance, easy recurrence, easy metastasis, and poor prognosis. This review discusses the origin, molecular, and biological features, functions, and applications of CSCs in HCC in recent years; the goal is to clarify the importance of CSCs in treatment and explore their potential value in HCC-targeted therapy.
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spelling pubmed-70685982020-03-24 Cancer Stem Cells: A Potential Breakthrough in HCC-Targeted Therapy Wu, Yafei Zhang, Jigang Zhang, Xue Zhou, Heming Liu, Gaolin Li, Qin Front Pharmacol Pharmacology Cancer stem cells (CSCs) are subpopulations of cells with stem cell characteristics that produce both cancerous and non-tumorigenic cells in tumor tissues. The literature reports that CSCs are closely related to the development of hepatocellular carcinoma (HCC) and promote the malignant features of HCC such as high invasion, drug resistance, easy recurrence, easy metastasis, and poor prognosis. This review discusses the origin, molecular, and biological features, functions, and applications of CSCs in HCC in recent years; the goal is to clarify the importance of CSCs in treatment and explore their potential value in HCC-targeted therapy. Frontiers Media S.A. 2020-03-06 /pmc/articles/PMC7068598/ /pubmed/32210805 http://dx.doi.org/10.3389/fphar.2020.00198 Text en Copyright © 2020 Wu, Zhang, Zhang, Zhou, Liu and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Wu, Yafei
Zhang, Jigang
Zhang, Xue
Zhou, Heming
Liu, Gaolin
Li, Qin
Cancer Stem Cells: A Potential Breakthrough in HCC-Targeted Therapy
title Cancer Stem Cells: A Potential Breakthrough in HCC-Targeted Therapy
title_full Cancer Stem Cells: A Potential Breakthrough in HCC-Targeted Therapy
title_fullStr Cancer Stem Cells: A Potential Breakthrough in HCC-Targeted Therapy
title_full_unstemmed Cancer Stem Cells: A Potential Breakthrough in HCC-Targeted Therapy
title_short Cancer Stem Cells: A Potential Breakthrough in HCC-Targeted Therapy
title_sort cancer stem cells: a potential breakthrough in hcc-targeted therapy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068598/
https://www.ncbi.nlm.nih.gov/pubmed/32210805
http://dx.doi.org/10.3389/fphar.2020.00198
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