Simultaneous pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer: A case report

We report a fatal case of pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer. A 77-year-old man was aware of eye ptosis and diplopia after three weeks from first infusion of pembrolizumab, an anti-programmed cell death protein 1 monoclonal antibodies....

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Autores principales: Takai, Manabu, Kato, Daiki, Iinuma, Koji, Maekawa, Yuka Muramatsu, Nakane, Keita, Tsuchiya, Tomohiro, Yokoi, Shigeaki, Koie, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068635/
https://www.ncbi.nlm.nih.gov/pubmed/32190548
http://dx.doi.org/10.1016/j.eucr.2020.101145
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author Takai, Manabu
Kato, Daiki
Iinuma, Koji
Maekawa, Yuka Muramatsu
Nakane, Keita
Tsuchiya, Tomohiro
Yokoi, Shigeaki
Koie, Takuya
author_facet Takai, Manabu
Kato, Daiki
Iinuma, Koji
Maekawa, Yuka Muramatsu
Nakane, Keita
Tsuchiya, Tomohiro
Yokoi, Shigeaki
Koie, Takuya
author_sort Takai, Manabu
collection PubMed
description We report a fatal case of pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer. A 77-year-old man was aware of eye ptosis and diplopia after three weeks from first infusion of pembrolizumab, an anti-programmed cell death protein 1 monoclonal antibodies. He was diagnosed with myasthenia gravis, because he was positive on the edrophonium test and acetylcholine receptor antibody. As his echocardiography also revealed diffuse loss in wall motion with ejection fraction 29%, he was strongly suspected myocarditis. Although he was treated with prednisone and intravenous immunoglobulin, he was suddenly in cardiac arrest and passed away.
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spelling pubmed-70686352020-03-18 Simultaneous pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer: A case report Takai, Manabu Kato, Daiki Iinuma, Koji Maekawa, Yuka Muramatsu Nakane, Keita Tsuchiya, Tomohiro Yokoi, Shigeaki Koie, Takuya Urol Case Rep Oncology We report a fatal case of pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer. A 77-year-old man was aware of eye ptosis and diplopia after three weeks from first infusion of pembrolizumab, an anti-programmed cell death protein 1 monoclonal antibodies. He was diagnosed with myasthenia gravis, because he was positive on the edrophonium test and acetylcholine receptor antibody. As his echocardiography also revealed diffuse loss in wall motion with ejection fraction 29%, he was strongly suspected myocarditis. Although he was treated with prednisone and intravenous immunoglobulin, he was suddenly in cardiac arrest and passed away. Elsevier 2020-02-26 /pmc/articles/PMC7068635/ /pubmed/32190548 http://dx.doi.org/10.1016/j.eucr.2020.101145 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Takai, Manabu
Kato, Daiki
Iinuma, Koji
Maekawa, Yuka Muramatsu
Nakane, Keita
Tsuchiya, Tomohiro
Yokoi, Shigeaki
Koie, Takuya
Simultaneous pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer: A case report
title Simultaneous pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer: A case report
title_full Simultaneous pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer: A case report
title_fullStr Simultaneous pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer: A case report
title_full_unstemmed Simultaneous pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer: A case report
title_short Simultaneous pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer: A case report
title_sort simultaneous pembrolizumab-induced myasthenia gravis and myocarditis in a patient with metastatic bladder cancer: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068635/
https://www.ncbi.nlm.nih.gov/pubmed/32190548
http://dx.doi.org/10.1016/j.eucr.2020.101145
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