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MutaBind2: Predicting the Impacts of Single and Multiple Mutations on Protein-Protein Interactions
Missense mutations may affect proteostasis by destabilizing or over-stabilizing protein complexes and changing the pathway flux. Predicting the effects of stabilizing mutations on protein-protein interactions is notoriously difficult because existing experimental sets are skewed toward mutations red...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068639/ https://www.ncbi.nlm.nih.gov/pubmed/32169820 http://dx.doi.org/10.1016/j.isci.2020.100939 |