iCa(2+) Flux, ROS and IL-10 Determines Cytotoxic, and Suppressor T Cell Functions in Chronic Human Viral Infections

Exhaustion of CD8(+) T cells and increased IL-10 production is well-known in chronic viral infections but mechanisms leading to loss of their cytotoxic capabilities and consequent exhaustion remain unclear. Exhausted CD8(+)T cells also called T suppressors are highly immune suppressive with altered...

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Detalles Bibliográficos
Autores principales: Mohanty, Subhasmita, Barik, Prakash, Debata, Nagen, Nagarajan, Perumal, Devadas, Satish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068714/
https://www.ncbi.nlm.nih.gov/pubmed/32210950
http://dx.doi.org/10.3389/fimmu.2020.00083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068714/
https://www.ncbi.nlm.nih.gov/pubmed/32210950
http://dx.doi.org/10.3389/fimmu.2020.00083

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