A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest

High dose melphalan is commonly used as a conditioning regimen for autologous stem cell transplantation in multiple myeloma. There are reports of adverse cardiac events with melphalan manifested by supraventricular tachycardia and atrial fibrillation. Here, we report a rare case of a 58 year old fem...

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Autores principales: Ma, Liang-Liang, Liu, Ying, Jia, Si-Xun, Lv, Hai-Chen, Fang, Mei-Yun, Xia, Yun-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069049/
https://www.ncbi.nlm.nih.gov/pubmed/32190351
http://dx.doi.org/10.1186/s40959-020-0059-0
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author Ma, Liang-Liang
Liu, Ying
Jia, Si-Xun
Lv, Hai-Chen
Fang, Mei-Yun
Xia, Yun-Long
author_facet Ma, Liang-Liang
Liu, Ying
Jia, Si-Xun
Lv, Hai-Chen
Fang, Mei-Yun
Xia, Yun-Long
author_sort Ma, Liang-Liang
collection PubMed
description High dose melphalan is commonly used as a conditioning regimen for autologous stem cell transplantation in multiple myeloma. There are reports of adverse cardiac events with melphalan manifested by supraventricular tachycardia and atrial fibrillation. Here, we report a rare case of a 58 year old female with multiple myeloma, who developed sinus arrest after autologous stem cell transplantation using high dose melphalan as a conditioning regimen. It was severe and rare, therefore, monitoring for cardiac toxicity in patients receiving high-dose melphalan is mandatory.
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spelling pubmed-70690492020-03-18 A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest Ma, Liang-Liang Liu, Ying Jia, Si-Xun Lv, Hai-Chen Fang, Mei-Yun Xia, Yun-Long Cardiooncology Short Communication High dose melphalan is commonly used as a conditioning regimen for autologous stem cell transplantation in multiple myeloma. There are reports of adverse cardiac events with melphalan manifested by supraventricular tachycardia and atrial fibrillation. Here, we report a rare case of a 58 year old female with multiple myeloma, who developed sinus arrest after autologous stem cell transplantation using high dose melphalan as a conditioning regimen. It was severe and rare, therefore, monitoring for cardiac toxicity in patients receiving high-dose melphalan is mandatory. BioMed Central 2020-03-13 /pmc/articles/PMC7069049/ /pubmed/32190351 http://dx.doi.org/10.1186/s40959-020-0059-0 Text en © The Author(s). 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Communication
Ma, Liang-Liang
Liu, Ying
Jia, Si-Xun
Lv, Hai-Chen
Fang, Mei-Yun
Xia, Yun-Long
A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest
title A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest
title_full A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest
title_fullStr A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest
title_full_unstemmed A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest
title_short A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest
title_sort case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069049/
https://www.ncbi.nlm.nih.gov/pubmed/32190351
http://dx.doi.org/10.1186/s40959-020-0059-0
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