The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma

Background: Human organic cation transporter 2 (OCT2) is the most abundant and important uptake transporter involved in the renal excretion of cationic drugs. Abnormal hypermethylation- mediated silencing of OCT2 results in oxaliplatin resistance in renal cell carcinoma (RCC). The epigenetic activat...

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Detalles Bibliográficos
Autores principales: Chen, Lu, Wang, Zeyang, Xu, Qingwen, Liu, Yuxi, Chen, Le, Guo, Suhang, Wang, Hua, Zeng, Kui, Liu, Junqing, Zeng, Su, Yu, Lushan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069078/
https://www.ncbi.nlm.nih.gov/pubmed/32206108
http://dx.doi.org/10.7150/thno.39944

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