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Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study

BACKGROUND: Prenatal phthalate exposure has been suggested to alter immune responses and increase the risk of asthma, eczema and rhinitis. However, few studies have examined the effects in prospective cohorts and only one examined rhinitis. We therefore studied associations between maternal urinary...

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Autores principales: Jøhnk, Camilla, Høst, Arne, Husby, Steffen, Schoeters, Greet, Timmermann, Clara Amalie Gade, Kyhl, Henriette Boye, Beck, Iben Have, Andersson, Anna-Maria, Frederiksen, Hanne, Jensen, Tina Kold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069194/
https://www.ncbi.nlm.nih.gov/pubmed/32169083
http://dx.doi.org/10.1186/s12940-020-00586-x
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author Jøhnk, Camilla
Høst, Arne
Husby, Steffen
Schoeters, Greet
Timmermann, Clara Amalie Gade
Kyhl, Henriette Boye
Beck, Iben Have
Andersson, Anna-Maria
Frederiksen, Hanne
Jensen, Tina Kold
author_facet Jøhnk, Camilla
Høst, Arne
Husby, Steffen
Schoeters, Greet
Timmermann, Clara Amalie Gade
Kyhl, Henriette Boye
Beck, Iben Have
Andersson, Anna-Maria
Frederiksen, Hanne
Jensen, Tina Kold
author_sort Jøhnk, Camilla
collection PubMed
description BACKGROUND: Prenatal phthalate exposure has been suggested to alter immune responses and increase the risk of asthma, eczema and rhinitis. However, few studies have examined the effects in prospective cohorts and only one examined rhinitis. We therefore studied associations between maternal urinary concentrations of phthalate metabolites and asthma, eczema and rhinitis in offspring aged 5 years. METHODS: From 552 pregnant women in the Odense Child Cohort, we quantified urinary concentrations of 12 phthalate metabolites in third trimester. We assessed asthma, rhinitis and eczema in their offspring at age 5 years with a questionnaire based on the International Study of Asthma and Allergies in Childhood (ISAAC), and conducted logistic regression adjusting for relevant confounders. RESULTS: 7.4% of the children had asthma, 11.7% eczema and 9.2% rhinitis. Phthalate exposure was low compared to previous cohorts. No significant associations between prenatal phthalate exposure and asthma were found. Odds ratios (ORs) of child rhinitis with a doubling in ΣDiNP(m) and di-2-ethylhexyl phthalate metabolite (ΣDEHP(m)) concentrations were, respectively, 1.15 (95% confidence interval (CI) 0.97,1.36) and 1.21 (CI 0.93,1.58). The OR of eczema when doubling ΣDiNP(m) was 1.24 (CI 1.00,1.55), whereas the OR of using medicine against eczema when doubling a di-ethyl phthalate (DEP) metabolite was 0.81 (CI 0.68,0.96). CONCLUSION: The lack of association between maternal phthalate exposure and asthma in the offspring may be due to low exposure and difficulties in determining asthma in 5-year-olds. The higher odds of rhinitis may raise public concern but further research in larger cohorts of older children is warranted.
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spelling pubmed-70691942020-03-18 Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study Jøhnk, Camilla Høst, Arne Husby, Steffen Schoeters, Greet Timmermann, Clara Amalie Gade Kyhl, Henriette Boye Beck, Iben Have Andersson, Anna-Maria Frederiksen, Hanne Jensen, Tina Kold Environ Health Research BACKGROUND: Prenatal phthalate exposure has been suggested to alter immune responses and increase the risk of asthma, eczema and rhinitis. However, few studies have examined the effects in prospective cohorts and only one examined rhinitis. We therefore studied associations between maternal urinary concentrations of phthalate metabolites and asthma, eczema and rhinitis in offspring aged 5 years. METHODS: From 552 pregnant women in the Odense Child Cohort, we quantified urinary concentrations of 12 phthalate metabolites in third trimester. We assessed asthma, rhinitis and eczema in their offspring at age 5 years with a questionnaire based on the International Study of Asthma and Allergies in Childhood (ISAAC), and conducted logistic regression adjusting for relevant confounders. RESULTS: 7.4% of the children had asthma, 11.7% eczema and 9.2% rhinitis. Phthalate exposure was low compared to previous cohorts. No significant associations between prenatal phthalate exposure and asthma were found. Odds ratios (ORs) of child rhinitis with a doubling in ΣDiNP(m) and di-2-ethylhexyl phthalate metabolite (ΣDEHP(m)) concentrations were, respectively, 1.15 (95% confidence interval (CI) 0.97,1.36) and 1.21 (CI 0.93,1.58). The OR of eczema when doubling ΣDiNP(m) was 1.24 (CI 1.00,1.55), whereas the OR of using medicine against eczema when doubling a di-ethyl phthalate (DEP) metabolite was 0.81 (CI 0.68,0.96). CONCLUSION: The lack of association between maternal phthalate exposure and asthma in the offspring may be due to low exposure and difficulties in determining asthma in 5-year-olds. The higher odds of rhinitis may raise public concern but further research in larger cohorts of older children is warranted. BioMed Central 2020-03-13 /pmc/articles/PMC7069194/ /pubmed/32169083 http://dx.doi.org/10.1186/s12940-020-00586-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Jøhnk, Camilla
Høst, Arne
Husby, Steffen
Schoeters, Greet
Timmermann, Clara Amalie Gade
Kyhl, Henriette Boye
Beck, Iben Have
Andersson, Anna-Maria
Frederiksen, Hanne
Jensen, Tina Kold
Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study
title Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study
title_full Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study
title_fullStr Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study
title_full_unstemmed Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study
title_short Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study
title_sort maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069194/
https://www.ncbi.nlm.nih.gov/pubmed/32169083
http://dx.doi.org/10.1186/s12940-020-00586-x
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