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Exploring the Activation Mechanism of the mGlu5 Transmembrane Domain

As a class C GPCR and regulator of synaptic activity, mGlu5 is an attractive drug target, potentially offering treatment for several neurologic and psychiatric disorders. As little is known about the activation mechanism of mGlu5 at a structural level, potential of mean force calculations linked to...

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Detalles Bibliográficos
Autores principales:	Lans, Isaias, Díaz, Óscar, Dalton, James A. R., Giraldo, Jesús
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069277/ https://www.ncbi.nlm.nih.gov/pubmed/32211419 http://dx.doi.org/10.3389/fmolb.2020.00038

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