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The significance of chemokine CXCL-8 in esophageal carcinoma

Chemokines are a group of small molecular weight proteins that are structurally related. These molecules play an important role in the growth, differentiation and activation of many types of cells [1, 2]. Chemokines are synthesized mostly by leukocytes and act through their cognate G-protein coupled...

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Autores principales: Łukaszewicz-Zając, Marta, Pączek, Sara, Mroczko, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069419/
https://www.ncbi.nlm.nih.gov/pubmed/32190161
http://dx.doi.org/10.5114/aoms.2017.71933
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author Łukaszewicz-Zając, Marta
Pączek, Sara
Mroczko, Barbara
author_facet Łukaszewicz-Zając, Marta
Pączek, Sara
Mroczko, Barbara
author_sort Łukaszewicz-Zając, Marta
collection PubMed
description Chemokines are a group of small molecular weight proteins that are structurally related. These molecules play an important role in the growth, differentiation and activation of many types of cells [1, 2]. Chemokines are synthesized mostly by leukocytes and act through their cognate G-protein coupled receptors to cause a cellular response, such as migration, adhesion or chemotaxis [1, 3]. The chemokine family has been classified into four classes: CC, CXC, CX3C, and (X), based on the arrangement of N-terminal cysteine residues [4]. These small peptides may also be grouped into inflammatory, homeostatic or dual function chemokines. Inflammatory chemokines can be induced during an immune response, whereas homeostatic chemokines are involved in control of cell migration [5]. The chemokine receptors are seven-transmembrane receptors coupled to G-proteins, that consist of an N-terminus outside the cell surface, three extracellular and three intracellular loops as well as a C-terminus in the cytoplasm [6, 7].
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spelling pubmed-70694192020-03-18 The significance of chemokine CXCL-8 in esophageal carcinoma Łukaszewicz-Zając, Marta Pączek, Sara Mroczko, Barbara Arch Med Sci Letter to the Editor Chemokines are a group of small molecular weight proteins that are structurally related. These molecules play an important role in the growth, differentiation and activation of many types of cells [1, 2]. Chemokines are synthesized mostly by leukocytes and act through their cognate G-protein coupled receptors to cause a cellular response, such as migration, adhesion or chemotaxis [1, 3]. The chemokine family has been classified into four classes: CC, CXC, CX3C, and (X), based on the arrangement of N-terminal cysteine residues [4]. These small peptides may also be grouped into inflammatory, homeostatic or dual function chemokines. Inflammatory chemokines can be induced during an immune response, whereas homeostatic chemokines are involved in control of cell migration [5]. The chemokine receptors are seven-transmembrane receptors coupled to G-proteins, that consist of an N-terminus outside the cell surface, three extracellular and three intracellular loops as well as a C-terminus in the cytoplasm [6, 7]. Termedia Publishing House 2020-02-04 /pmc/articles/PMC7069419/ /pubmed/32190161 http://dx.doi.org/10.5114/aoms.2017.71933 Text en Copyright: © 2020 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Letter to the Editor
Łukaszewicz-Zając, Marta
Pączek, Sara
Mroczko, Barbara
The significance of chemokine CXCL-8 in esophageal carcinoma
title The significance of chemokine CXCL-8 in esophageal carcinoma
title_full The significance of chemokine CXCL-8 in esophageal carcinoma
title_fullStr The significance of chemokine CXCL-8 in esophageal carcinoma
title_full_unstemmed The significance of chemokine CXCL-8 in esophageal carcinoma
title_short The significance of chemokine CXCL-8 in esophageal carcinoma
title_sort significance of chemokine cxcl-8 in esophageal carcinoma
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069419/
https://www.ncbi.nlm.nih.gov/pubmed/32190161
http://dx.doi.org/10.5114/aoms.2017.71933
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