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The significance of chemokine CXCL-8 in esophageal carcinoma
Chemokines are a group of small molecular weight proteins that are structurally related. These molecules play an important role in the growth, differentiation and activation of many types of cells [1, 2]. Chemokines are synthesized mostly by leukocytes and act through their cognate G-protein coupled...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069419/ https://www.ncbi.nlm.nih.gov/pubmed/32190161 http://dx.doi.org/10.5114/aoms.2017.71933 |
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author | Łukaszewicz-Zając, Marta Pączek, Sara Mroczko, Barbara |
author_facet | Łukaszewicz-Zając, Marta Pączek, Sara Mroczko, Barbara |
author_sort | Łukaszewicz-Zając, Marta |
collection | PubMed |
description | Chemokines are a group of small molecular weight proteins that are structurally related. These molecules play an important role in the growth, differentiation and activation of many types of cells [1, 2]. Chemokines are synthesized mostly by leukocytes and act through their cognate G-protein coupled receptors to cause a cellular response, such as migration, adhesion or chemotaxis [1, 3]. The chemokine family has been classified into four classes: CC, CXC, CX3C, and (X), based on the arrangement of N-terminal cysteine residues [4]. These small peptides may also be grouped into inflammatory, homeostatic or dual function chemokines. Inflammatory chemokines can be induced during an immune response, whereas homeostatic chemokines are involved in control of cell migration [5]. The chemokine receptors are seven-transmembrane receptors coupled to G-proteins, that consist of an N-terminus outside the cell surface, three extracellular and three intracellular loops as well as a C-terminus in the cytoplasm [6, 7]. |
format | Online Article Text |
id | pubmed-7069419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-70694192020-03-18 The significance of chemokine CXCL-8 in esophageal carcinoma Łukaszewicz-Zając, Marta Pączek, Sara Mroczko, Barbara Arch Med Sci Letter to the Editor Chemokines are a group of small molecular weight proteins that are structurally related. These molecules play an important role in the growth, differentiation and activation of many types of cells [1, 2]. Chemokines are synthesized mostly by leukocytes and act through their cognate G-protein coupled receptors to cause a cellular response, such as migration, adhesion or chemotaxis [1, 3]. The chemokine family has been classified into four classes: CC, CXC, CX3C, and (X), based on the arrangement of N-terminal cysteine residues [4]. These small peptides may also be grouped into inflammatory, homeostatic or dual function chemokines. Inflammatory chemokines can be induced during an immune response, whereas homeostatic chemokines are involved in control of cell migration [5]. The chemokine receptors are seven-transmembrane receptors coupled to G-proteins, that consist of an N-terminus outside the cell surface, three extracellular and three intracellular loops as well as a C-terminus in the cytoplasm [6, 7]. Termedia Publishing House 2020-02-04 /pmc/articles/PMC7069419/ /pubmed/32190161 http://dx.doi.org/10.5114/aoms.2017.71933 Text en Copyright: © 2020 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Letter to the Editor Łukaszewicz-Zając, Marta Pączek, Sara Mroczko, Barbara The significance of chemokine CXCL-8 in esophageal carcinoma |
title | The significance of chemokine CXCL-8 in esophageal carcinoma |
title_full | The significance of chemokine CXCL-8 in esophageal carcinoma |
title_fullStr | The significance of chemokine CXCL-8 in esophageal carcinoma |
title_full_unstemmed | The significance of chemokine CXCL-8 in esophageal carcinoma |
title_short | The significance of chemokine CXCL-8 in esophageal carcinoma |
title_sort | significance of chemokine cxcl-8 in esophageal carcinoma |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069419/ https://www.ncbi.nlm.nih.gov/pubmed/32190161 http://dx.doi.org/10.5114/aoms.2017.71933 |
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