Role of Mitophagy in Cardiovascular Disease

Cardiovascular disease is the leading cause of mortality worldwide, and mitochondrial dysfunction is the primary contributor to these disorders. Recent studies have elaborated on selective autophagy-mitophagy, which eliminates damaged and dysfunctional mitochondria, stabilizes mitochondrial structur...

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Detalles Bibliográficos
Autores principales: Yang, Yibo, Li, Tianyi, Li, Zhibo, Liu, Ning, Yan, Youyou, Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069452/
https://www.ncbi.nlm.nih.gov/pubmed/32257551
http://dx.doi.org/10.14336/AD.2019.0518
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author Yang, Yibo
Li, Tianyi
Li, Zhibo
Liu, Ning
Yan, Youyou
Liu, Bin
author_facet Yang, Yibo
Li, Tianyi
Li, Zhibo
Liu, Ning
Yan, Youyou
Liu, Bin
author_sort Yang, Yibo
collection PubMed
description Cardiovascular disease is the leading cause of mortality worldwide, and mitochondrial dysfunction is the primary contributor to these disorders. Recent studies have elaborated on selective autophagy-mitophagy, which eliminates damaged and dysfunctional mitochondria, stabilizes mitochondrial structure and function, and maintains cell survival and growth. Numerous recent studies have reported that mitophagy plays an important role in the pathogenesis of various cardiovascular diseases. This review summarizes the mechanisms underlying mitophagy and advancements in studies on the role of mitophagy in cardiovascular disease.
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spelling pubmed-70694522020-04-01 Role of Mitophagy in Cardiovascular Disease Yang, Yibo Li, Tianyi Li, Zhibo Liu, Ning Yan, Youyou Liu, Bin Aging Dis Review Article Cardiovascular disease is the leading cause of mortality worldwide, and mitochondrial dysfunction is the primary contributor to these disorders. Recent studies have elaborated on selective autophagy-mitophagy, which eliminates damaged and dysfunctional mitochondria, stabilizes mitochondrial structure and function, and maintains cell survival and growth. Numerous recent studies have reported that mitophagy plays an important role in the pathogenesis of various cardiovascular diseases. This review summarizes the mechanisms underlying mitophagy and advancements in studies on the role of mitophagy in cardiovascular disease. JKL International LLC 2020-03-09 /pmc/articles/PMC7069452/ /pubmed/32257551 http://dx.doi.org/10.14336/AD.2019.0518 Text en Copyright: © 2020 Yang et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review Article
Yang, Yibo
Li, Tianyi
Li, Zhibo
Liu, Ning
Yan, Youyou
Liu, Bin
Role of Mitophagy in Cardiovascular Disease
title Role of Mitophagy in Cardiovascular Disease
title_full Role of Mitophagy in Cardiovascular Disease
title_fullStr Role of Mitophagy in Cardiovascular Disease
title_full_unstemmed Role of Mitophagy in Cardiovascular Disease
title_short Role of Mitophagy in Cardiovascular Disease
title_sort role of mitophagy in cardiovascular disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069452/
https://www.ncbi.nlm.nih.gov/pubmed/32257551
http://dx.doi.org/10.14336/AD.2019.0518
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