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Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review

Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidativ...

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Detalles Bibliográficos
Autores principales: Tian, Jinfan, Popal, Mohammad Sharif, Huang, RongChong, Zhang, Min, Zhao, Xin, Zhang, Mingduo, Song, Xiantao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069461/
https://www.ncbi.nlm.nih.gov/pubmed/32257548
http://dx.doi.org/10.14336/AD.2019.09603
Descripción
Sumario:Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy.