Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review

Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidativ...

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Detalles Bibliográficos
Autores principales: Tian, Jinfan, Popal, Mohammad Sharif, Huang, RongChong, Zhang, Min, Zhao, Xin, Zhang, Mingduo, Song, Xiantao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069461/
https://www.ncbi.nlm.nih.gov/pubmed/32257548
http://dx.doi.org/10.14336/AD.2019.09603
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author Tian, Jinfan
Popal, Mohammad Sharif
Huang, RongChong
Zhang, Min
Zhao, Xin
Zhang, Mingduo
Song, Xiantao
author_facet Tian, Jinfan
Popal, Mohammad Sharif
Huang, RongChong
Zhang, Min
Zhao, Xin
Zhang, Mingduo
Song, Xiantao
author_sort Tian, Jinfan
collection PubMed
description Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy.
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spelling pubmed-70694612020-04-01 Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review Tian, Jinfan Popal, Mohammad Sharif Huang, RongChong Zhang, Min Zhao, Xin Zhang, Mingduo Song, Xiantao Aging Dis Review Article Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy. JKL International LLC 2020-03-09 /pmc/articles/PMC7069461/ /pubmed/32257548 http://dx.doi.org/10.14336/AD.2019.09603 Text en Copyright: © 2020 Tian et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review Article
Tian, Jinfan
Popal, Mohammad Sharif
Huang, RongChong
Zhang, Min
Zhao, Xin
Zhang, Mingduo
Song, Xiantao
Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review
title Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review
title_full Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review
title_fullStr Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review
title_full_unstemmed Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review
title_short Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review
title_sort caveolin as a novel potential therapeutic target in cardiac and vascular diseases: a mini review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069461/
https://www.ncbi.nlm.nih.gov/pubmed/32257548
http://dx.doi.org/10.14336/AD.2019.09603
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