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Understanding the Physiological Links Between Physical Frailty and Cognitive Decline
Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidenc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069469/ https://www.ncbi.nlm.nih.gov/pubmed/32257550 http://dx.doi.org/10.14336/AD.2019.0521 |
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author | Ma, Lina Chan, Piu |
author_facet | Ma, Lina Chan, Piu |
author_sort | Ma, Lina |
collection | PubMed |
description | Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical frailty to cognitive decline, a complete understanding of the underpinning biological basis of the two disorders remains fragmented. This narrative review discusses insights into the potential roles of chronic inflammation, impaired hypothalamic-pituitary axis stress response, imbalanced energy metabolism, mitochondrial dysfunction, oxidative stress, and neuroendocrine dysfunction linking physical frailty with cognitive decline. We highlight the importance of easier identification of strategic approaches delaying the progression and onset of physical frailty and cognitive decline as well as preventing disability in the older population. |
format | Online Article Text |
id | pubmed-7069469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-70694692020-04-01 Understanding the Physiological Links Between Physical Frailty and Cognitive Decline Ma, Lina Chan, Piu Aging Dis Review Article Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical frailty to cognitive decline, a complete understanding of the underpinning biological basis of the two disorders remains fragmented. This narrative review discusses insights into the potential roles of chronic inflammation, impaired hypothalamic-pituitary axis stress response, imbalanced energy metabolism, mitochondrial dysfunction, oxidative stress, and neuroendocrine dysfunction linking physical frailty with cognitive decline. We highlight the importance of easier identification of strategic approaches delaying the progression and onset of physical frailty and cognitive decline as well as preventing disability in the older population. JKL International LLC 2020-03-09 /pmc/articles/PMC7069469/ /pubmed/32257550 http://dx.doi.org/10.14336/AD.2019.0521 Text en Copyright: © 2020 Ma et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Review Article Ma, Lina Chan, Piu Understanding the Physiological Links Between Physical Frailty and Cognitive Decline |
title | Understanding the Physiological Links Between Physical Frailty and Cognitive Decline |
title_full | Understanding the Physiological Links Between Physical Frailty and Cognitive Decline |
title_fullStr | Understanding the Physiological Links Between Physical Frailty and Cognitive Decline |
title_full_unstemmed | Understanding the Physiological Links Between Physical Frailty and Cognitive Decline |
title_short | Understanding the Physiological Links Between Physical Frailty and Cognitive Decline |
title_sort | understanding the physiological links between physical frailty and cognitive decline |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069469/ https://www.ncbi.nlm.nih.gov/pubmed/32257550 http://dx.doi.org/10.14336/AD.2019.0521 |
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