RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation

Mediator of IRF3 activation (MITA, also named as STING/ERIS/MPYS/TMEM173), is essential to DNA virus- or cytosolic DNA-triggered innate immune responses. In this study, we demonstrated the negative regulatory role of RING-finger protein (RNF) 90 in innate immune responses targeting MITA. RNF90 promo...

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Detalles Bibliográficos
Autores principales: Yang, Bo, Liu, Yue, Cui, Yuhan, Song, Di, Zhang, Ge, Ma, Shujun, Liu, Yanzi, Chen, Mengmeng, Chen, Fan, Wang, Hui, Wang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069649/
https://www.ncbi.nlm.nih.gov/pubmed/32126128
http://dx.doi.org/10.1371/journal.ppat.1008387

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