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Enhanced ER-associated degradation of HMG CoA reductase causes embryonic lethality associated with Ubiad1 deficiency

UbiA prenyltransferase domain-containing protein-1 (UBIAD1) synthesizes the vitamin K subtype menaquinone-4 (MK-4). Previous studies in cultured cells (Schumacher et al., 2015) revealed that UBIAD1 also inhibits endoplasmic reticulum (ER)-associated degradation (ERAD) of ubiquitinated HMG CoA reduct...

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Detalles Bibliográficos
Autores principales:	Jo, Youngah, Kim, Steven S, Garland, Kristina, Fuentes, Iris, DiCarlo, Lisa M, Ellis, Jessie L, Fu, Xueyan, Booth, Sarah L, Evers, Bret M, DeBose-Boyd, Russell A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069719/ https://www.ncbi.nlm.nih.gov/pubmed/32118581 http://dx.doi.org/10.7554/eLife.54841

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