Cargando…

Efficacy of FLU-v, a broad-spectrum influenza vaccine, in a randomized phase IIb human influenza challenge study

FLU-v, developed by PepTcell (SEEK), is a peptide vaccine aiming to provide a broadly protective cellular immune response against influenza A and B. A randomized, double-blind, placebo-controlled, single-center, phase IIb efficacy and safety trial was conducted. One hundred and fifty-three healthy i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pleguezuelos, Olga, James, Emma, Fernandez, Ana, Lopes, Victor, Rosas, Luz Angela, Cervantes-Medina, Adriana, Cleath, Jason, Edwards, Kristina, Neitzey, Dana, Gu, Wenjuan, Hunsberger, Sally, Taubenberger, Jeffery K., Stoloff, Gregory, Memoli, Matthew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069936/ https://www.ncbi.nlm.nih.gov/pubmed/32194999 http://dx.doi.org/10.1038/s41541-020-0174-9

Ejemplares similares

FLU-v, a Broad-Spectrum Influenza Vaccine, Induces Cross-Reactive Cellular Immune Responses in Humans Measured by Dual IFN-γ and Granzyme B ELISpot Assay
por: Oftung, Fredrik, et al.
Publicado: (2022)

2750. Sequential Influenza A H1N1 and Influenza A H3N2 Challenge Infections in Healthy Volunteers
por: Han, Alison, et al.
Publicado: (2019)

Evaluation of the immunogenicity and safety of different doses and formulations of a broad spectrum influenza vaccine (FLU-v) developed by SEEK: study protocol for a single-center, randomized, double-blind and placebo-controlled clinical phase IIb trial
por: van Doorn, Eva, et al.
Publicado: (2017)

1522. Safety and Efficacy of CR6261 in an Influenza A H1N1 Healthy Human Challenge Model
por: Han, Alison, et al.
Publicado: (2020)

H5Nx Panzootic Bird Flu—Influenza’s Newest Worldwide Evolutionary Tour
por: Taubenberger, Jeffery K., et al.
Publicado: (2017)

Influenza in pregnancy
por: Memoli, Matthew J., et al.
Publicado: (2012)

Influenza Neuraminidase: A Neglected Protein and Its Potential for a Better Influenza Vaccine
por: Giurgea, Luca T., et al.
Publicado: (2020)

Evaluation of Preexisting Anti-Hemagglutinin Stalk Antibody as a Correlate of Protection in a Healthy Volunteer Challenge with Influenza A/H1N1pdm Virus
por: Park, Jae-Keun, et al.
Publicado: (2018)

723. Validation of a Wild-Type Influenza A/Texas-Like H3N2 Human Challenge Model with Comparison to the Validated A(H1N1)pdm09 Model
por: Han, Alison, et al.
Publicado: (2018)

Influenza’s Newest Trick
por: Taubenberger, Jeffery K.
Publicado: (2019)

Influenza Revisited
por: Taubenberger, Jeffery K., et al.
Publicado: (2006)

Using the Influenza Patient-reported Outcome (FLU-PRO) diary to evaluate symptoms of influenza viral infection in a healthy human challenge model
por: Han, Alison, et al.
Publicado: (2018)

Evaluating Symptom Severity of Influenza Viral Infection Using the Influenza Patient-reported Outcomes Instrument (FLU-PRO) in a Healthy Human Challenge Model
por: Han, Alison, et al.
Publicado: (2017)

An avian outbreak associated with panzootic equine influenza in 1872: an early example of highly pathogenic avian influenza?
por: Morens, David M., et al.
Publicado: (2010)

Influenza Forecasting with Google Flu Trends
por: Dugas, Andrea Freyer, et al.
Publicado: (2013)

Influenza Forecasting with Google Flu Trends
por: Dugas, Andrea F., et al.
Publicado: (2013)

1918 Influenza: the Mother of All Pandemics
por: Taubenberger, Jeffery K., et al.
Publicado: (2006)

Influenza Viruses: Breaking All the Rules
por: Taubenberger, Jeffery K., et al.
Publicado: (2013)

Influenza and the Origins of The Phillips Collection, Washington, DC
por: Morens, David M., et al.
Publicado: (2006)

1918 Influenza, a Puzzle with Missing Pieces
por: Morens, David M., et al.
Publicado: (2012)

An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus
por: Schwartzman, Louis M., et al.
Publicado: (2015)

1524. Sex Differences in Influenza: The Challenge Study Experience
por: Giurgea, Luca, et al.
Publicado: (2020)

Differential Effects of Influenza Virus NA, HA Head, and HA Stalk Antibodies on Peripheral Blood Leukocyte Gene Expression during Human Infection
por: Walters, Kathie-Anne, et al.
Publicado: (2019)

Down with the Flu: Hyponatremia in a patient with influenza
por: Pathak, Ranjan, et al.
Publicado: (2015)

Avian influenza aided readiness for swine flu
por: Hayden, Erika Check
Publicado: (2009)

Performance of the inFLUenza Patient-Reported Outcome (FLU-PRO) diary in patients with influenza-like illness (ILI)
por: Powers, John H., et al.
Publicado: (2018)

Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic
por: Morens, David M, et al.
Publicado: (2019)

The Natural History of Influenza Infection in the Severely Immunocompromised vs Nonimmunocompromised Hosts
por: Memoli, Matthew J., et al.
Publicado: (2014)

The effect of calcium and magnesium on activity, immunogenicity, and efficacy of a recombinant N1/N2 neuraminidase vaccine
por: Giurgea, Luca T., et al.
Publicado: (2021)

Pandemic Flu: Clinical management of patients with an influenza-like illness during an influenza pandemic
Publicado: (2006)

FLU, an amino acid substitution model for influenza proteins
por: Dang, Cuong Cao, et al.
Publicado: (2010)

FluBlok, a recombinant hemagglutinin influenza vaccine
por: Cox, Manon M.J., et al.
Publicado: (2008)

Optimal Time of Flu Shot: Influenza B Is the Problem
por: Jo, Dae Sun
Publicado: (2019)

Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus
por: Reid, Ann H., et al.
Publicado: (2004)

FluShuffle and FluResort: new algorithms to identify reassorted strains of the influenza virus by mass spectrometry
por: Lun, Aaron TL, et al.
Publicado: (2012)

Modeling influenza epidemics and pandemics: insights into the future of swine flu (H1N1)
por: Coburn, Brian J, et al.
Publicado: (2009)

Development of live cultural pandemic influenza vaccine Vector-Flu
por: Nechaeva, Elena A, et al.
Publicado: (2011)

Influenza, swine flu, sperm quality and infertility: A story
por: Wiwanitkit, Viroj
Publicado: (2010)

The neuropsychiatric aspects of influenza/swine flu: A selective review
por: Manjunatha, Narayana, et al.
Publicado: (2011)

Real-time Laboratory-Based Influenza Surveillance with Xpert Flu
por: Dugas, Andrea, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_u2uuaq8mhmo3sr7h1fg5uupqr8