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Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

The relationship between amyloid-β (Aβ) species and tau pathology in Alzheimer’s disease (AD) is not fully understood. Here, we provide direct evidence that Aβ42/40 ratio, not total Aβ level, plays a critical role in inducing neurofibrillary tangles (NTFs) in human neurons. Using 3D-differentiated c...

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Detalles Bibliográficos
Autores principales:	Kwak, Sang Su, Washicosky, Kevin J., Brand, Emma, von Maydell, Djuna, Aronson, Jenna, Kim, Susan, Capen, Diane E., Cetinbas, Murat, Sadreyev, Ruslan, Ning, Shen, Bylykbashi, Enjana, Xia, Weiming, Wagner, Steven L., Choi, Se Hoon, Tanzi, Rudolph E., Kim, Doo Yeon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070004/ https://www.ncbi.nlm.nih.gov/pubmed/32170138 http://dx.doi.org/10.1038/s41467-020-15120-3

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