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A signaling hub of insulin receptor, dystrophin glycoprotein complex and plakoglobin regulates muscle size

Signaling through the insulin receptor governs central physiological functions related to cell growth and metabolism. Here we show by tandem native protein complex purification approach and super-resolution STED microscopy that insulin receptor activity requires association with the fundamental stru...

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Detalles Bibliográficos
Autores principales: Eid Mutlak, Yara, Aweida, Dina, Volodin, Alexandra, Ayalon, Bar, Dahan, Nitsan, Parnis, Anna, Cohen, Shenhav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070008/
https://www.ncbi.nlm.nih.gov/pubmed/32170063
http://dx.doi.org/10.1038/s41467-020-14895-9