Upregulation of large myelin protein zero leads to Charcot–Marie–Tooth disease-like neuropathy in mice

Charcot–Marie–Tooth (CMT) disease is a hereditary neuropathy mainly caused by gene mutation of peripheral myelin proteins including myelin protein zero (P0, MPZ). Large myelin protein zero (L-MPZ) is an isoform of P0 that contains an extended polypeptide synthesized by translational readthrough at t...

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Detalles Bibliográficos
Autores principales: Otani, Yoshinori, Ohno, Nobuhiko, Cui, Jingjing, Yamaguchi, Yoshihide, Baba, Hiroko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070019/
https://www.ncbi.nlm.nih.gov/pubmed/32170207
http://dx.doi.org/10.1038/s42003-020-0854-z

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