Western diet induces severe nonalcoholic steatohepatitis, ductular reaction, and hepatic fibrosis in liver CGI-58 knockout mice

Humans and rodents with Comparative Gene Identification-58 (CGI-58) mutations manifest nonalcoholic fatty liver disease (NAFLD). Here we show that liver CGI-58 knockout (LivKO) mice fed a Western diet rapidly develop advanced NAFLD, including nonalcoholic steatohepatitis (NASH) and hepatic fibrosis....

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Detalles Bibliográficos
Autores principales: Yang, Pan, Wang, Youlin, Tang, Weiqing, Sun, Weiwei, Ma, Yinyan, Lin, Shu, Jing, Jia, Jiang, Long, Shi, Hang, Song, Zhiyuan, Yu, Liqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070035/
https://www.ncbi.nlm.nih.gov/pubmed/32170127
http://dx.doi.org/10.1038/s41598-020-61473-6

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