Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation

Embryonic Stem Cell (ESC) differentiation requires complex cell signalling network dynamics, although the key molecular events remain poorly understood. Here, we use phosphoproteomics to identify an FGF4-mediated phosphorylation switch centred upon the key Ephrin receptor EPHA2 in differentiating ES...

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Detalles Bibliográficos
Autores principales: Fernandez-Alonso, Rosalia, Bustos, Francisco, Budzyk, Manon, Kumar, Pankaj, Helbig, Andreas O., Hukelmann, Jens, Lamond, Angus I., Lanner, Fredrik, Zhou, Houjiang, Petsalaki, Evangelia, Findlay, Greg M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070061/
https://www.ncbi.nlm.nih.gov/pubmed/32170114
http://dx.doi.org/10.1038/s41467-020-15173-4

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