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Model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine

BACKGROUND: Bile acids are multifaceted metabolic compounds that signal to cholesterol, glucose, and lipid homeostasis via receptors like the Farnesoid X Receptor (FXR) and transmembrane Takeda G protein‐coupled receptor 5 (TGR5). The postprandial increase in plasma bile acid concentrations is there...

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Autores principales: Meessen, Emma C. E., Sips, Fianne L. P., Eggink, Hannah M., Koehorst, Martijn, Romijn, Johannes A., Groen, Albert K., van Riel, Natal A. W., Soeters, Maarten R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070101/
https://www.ncbi.nlm.nih.gov/pubmed/32170845
http://dx.doi.org/10.14814/phy2.14358
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author Meessen, Emma C. E.
Sips, Fianne L. P.
Eggink, Hannah M.
Koehorst, Martijn
Romijn, Johannes A.
Groen, Albert K.
van Riel, Natal A. W.
Soeters, Maarten R.
author_facet Meessen, Emma C. E.
Sips, Fianne L. P.
Eggink, Hannah M.
Koehorst, Martijn
Romijn, Johannes A.
Groen, Albert K.
van Riel, Natal A. W.
Soeters, Maarten R.
author_sort Meessen, Emma C. E.
collection PubMed
description BACKGROUND: Bile acids are multifaceted metabolic compounds that signal to cholesterol, glucose, and lipid homeostasis via receptors like the Farnesoid X Receptor (FXR) and transmembrane Takeda G protein‐coupled receptor 5 (TGR5). The postprandial increase in plasma bile acid concentrations is therefore a potential metabolic signal. However, this postprandial response has a high interindividual variability. Such variability may affect bile acid receptor activation. METHODS: In this study, we analyzed the inter‐ and intraindividual variability of fasting and postprandial bile acid concentrations during three identical meals on separate days in eight healthy lean male subjects using a statistical and mathematical approach. MAIN FINDINGS: The postprandial bile acid responses exhibited large interindividual and intraindividual variability. The individual mathematical models, which represent the enterohepatic circulation of bile acids in each subject, suggest that interindividual variability results from quantitative and qualitative differences of distal active uptake, colon transit, and microbial bile acid transformation. Conversely, intraindividual variations in gallbladder kinetics can explain intraindividual differences in the postprandial responses. CONCLUSIONS: We conclude that there is considerable inter‐ and intraindividual variation in postprandial plasma bile acid levels. The presented personalized approach is a promising tool to identify unique characteristics of underlying physiological processes and can be applied to investigate bile acid metabolism in pathophysiological conditions.
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spelling pubmed-70701012020-03-17 Model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine Meessen, Emma C. E. Sips, Fianne L. P. Eggink, Hannah M. Koehorst, Martijn Romijn, Johannes A. Groen, Albert K. van Riel, Natal A. W. Soeters, Maarten R. Physiol Rep Original Research BACKGROUND: Bile acids are multifaceted metabolic compounds that signal to cholesterol, glucose, and lipid homeostasis via receptors like the Farnesoid X Receptor (FXR) and transmembrane Takeda G protein‐coupled receptor 5 (TGR5). The postprandial increase in plasma bile acid concentrations is therefore a potential metabolic signal. However, this postprandial response has a high interindividual variability. Such variability may affect bile acid receptor activation. METHODS: In this study, we analyzed the inter‐ and intraindividual variability of fasting and postprandial bile acid concentrations during three identical meals on separate days in eight healthy lean male subjects using a statistical and mathematical approach. MAIN FINDINGS: The postprandial bile acid responses exhibited large interindividual and intraindividual variability. The individual mathematical models, which represent the enterohepatic circulation of bile acids in each subject, suggest that interindividual variability results from quantitative and qualitative differences of distal active uptake, colon transit, and microbial bile acid transformation. Conversely, intraindividual variations in gallbladder kinetics can explain intraindividual differences in the postprandial responses. CONCLUSIONS: We conclude that there is considerable inter‐ and intraindividual variation in postprandial plasma bile acid levels. The presented personalized approach is a promising tool to identify unique characteristics of underlying physiological processes and can be applied to investigate bile acid metabolism in pathophysiological conditions. John Wiley and Sons Inc. 2020-03-13 /pmc/articles/PMC7070101/ /pubmed/32170845 http://dx.doi.org/10.14814/phy2.14358 Text en © 2020 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Meessen, Emma C. E.
Sips, Fianne L. P.
Eggink, Hannah M.
Koehorst, Martijn
Romijn, Johannes A.
Groen, Albert K.
van Riel, Natal A. W.
Soeters, Maarten R.
Model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine
title Model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine
title_full Model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine
title_fullStr Model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine
title_full_unstemmed Model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine
title_short Model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine
title_sort model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070101/
https://www.ncbi.nlm.nih.gov/pubmed/32170845
http://dx.doi.org/10.14814/phy2.14358
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