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The Characteristics and Nomogram for Primary Lung Papillary Adenocarcinoma

BACKGROUND: Primary pulmonary papillary adenocarcinoma (PA) is a specific and rare subtype of invasive pulmonary adenocarcinoma (ADC). The knowledge concerning the clinicopathologic features and prognosis of patients with primary pulmonary PA has not been clarified because of its rarity. METHODS: Th...

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Autores principales: Zhang, Yuqian, Xie, Hui, Zhang, Ziying, Zhang, Pengfei, Chen, Peng, Wang, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070103/
https://www.ncbi.nlm.nih.gov/pubmed/32195357
http://dx.doi.org/10.1515/med-2020-0014
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author Zhang, Yuqian
Xie, Hui
Zhang, Ziying
Zhang, Pengfei
Chen, Peng
Wang, Xiang
author_facet Zhang, Yuqian
Xie, Hui
Zhang, Ziying
Zhang, Pengfei
Chen, Peng
Wang, Xiang
author_sort Zhang, Yuqian
collection PubMed
description BACKGROUND: Primary pulmonary papillary adenocarcinoma (PA) is a specific and rare subtype of invasive pulmonary adenocarcinoma (ADC). The knowledge concerning the clinicopathologic features and prognosis of patients with primary pulmonary PA has not been clarified because of its rarity. METHODS: The clinical data of a total of 3391 patients with primary pulmonary PA were retrospectively analyzed to confirm their clinical characteristics and factors influencing prognosis and were in comparison with 3236 patients with non- PA pulmonary adenocarcinoma. All patients were histologically diagnosed between 1988 and 2015 in The Surveillance Epidemiology and End Results (SEER) database. A nomogram with satisfactory predictive performance was established to visually predict long-term survival of these patients. RESULTS AND CONCLUSION: Collectively, primary pulmonary PA is a rare pathological cancer and its prognosis is analogous to that of non-PA pulmonary adenocarcinoma. Older age, larger lesions, distant metastases, lymph node invasion, and poor pathological differentiation are correlative with unacceptable prognosis. Surgical intervention is conducive to reaping favorable prognosis. Unfortunately, radiotherapy or chemotherapy results of no significant effects on patient survival. In our study, a nomogram with prognostic function is formulated to confer individual prediction of overall survival (OS).
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spelling pubmed-70701032020-03-19 The Characteristics and Nomogram for Primary Lung Papillary Adenocarcinoma Zhang, Yuqian Xie, Hui Zhang, Ziying Zhang, Pengfei Chen, Peng Wang, Xiang Open Med (Wars) Research Article BACKGROUND: Primary pulmonary papillary adenocarcinoma (PA) is a specific and rare subtype of invasive pulmonary adenocarcinoma (ADC). The knowledge concerning the clinicopathologic features and prognosis of patients with primary pulmonary PA has not been clarified because of its rarity. METHODS: The clinical data of a total of 3391 patients with primary pulmonary PA were retrospectively analyzed to confirm their clinical characteristics and factors influencing prognosis and were in comparison with 3236 patients with non- PA pulmonary adenocarcinoma. All patients were histologically diagnosed between 1988 and 2015 in The Surveillance Epidemiology and End Results (SEER) database. A nomogram with satisfactory predictive performance was established to visually predict long-term survival of these patients. RESULTS AND CONCLUSION: Collectively, primary pulmonary PA is a rare pathological cancer and its prognosis is analogous to that of non-PA pulmonary adenocarcinoma. Older age, larger lesions, distant metastases, lymph node invasion, and poor pathological differentiation are correlative with unacceptable prognosis. Surgical intervention is conducive to reaping favorable prognosis. Unfortunately, radiotherapy or chemotherapy results of no significant effects on patient survival. In our study, a nomogram with prognostic function is formulated to confer individual prediction of overall survival (OS). De Gruyter 2020-02-20 /pmc/articles/PMC7070103/ /pubmed/32195357 http://dx.doi.org/10.1515/med-2020-0014 Text en © 2020 Yuqian Zhang et al., published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 Public License.
spellingShingle Research Article
Zhang, Yuqian
Xie, Hui
Zhang, Ziying
Zhang, Pengfei
Chen, Peng
Wang, Xiang
The Characteristics and Nomogram for Primary Lung Papillary Adenocarcinoma
title The Characteristics and Nomogram for Primary Lung Papillary Adenocarcinoma
title_full The Characteristics and Nomogram for Primary Lung Papillary Adenocarcinoma
title_fullStr The Characteristics and Nomogram for Primary Lung Papillary Adenocarcinoma
title_full_unstemmed The Characteristics and Nomogram for Primary Lung Papillary Adenocarcinoma
title_short The Characteristics and Nomogram for Primary Lung Papillary Adenocarcinoma
title_sort characteristics and nomogram for primary lung papillary adenocarcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070103/
https://www.ncbi.nlm.nih.gov/pubmed/32195357
http://dx.doi.org/10.1515/med-2020-0014
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