Cell‐permeable high‐affinity tracers for G(q) proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors

BACKGROUND AND PURPOSE: G proteins are intracellular switches that transduce and amplify extracellular signals from GPCRs. The G(q) protein subtypes, which are coupled to PLC activation, can act as oncogenes, and their expression was reported to be up‐regulated in cancer and inflammatory diseases. G...

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Detalles Bibliográficos
Autores principales: Kuschak, Markus, Namasivayam, Vigneshwaran, Rafehi, Muhammad, Voss, Jan H., Garg, Jaspal, Schlegel, Jonathan G., Abdelrahman, Aliaa, Kehraus, Stefan, Reher, Raphael, Küppers, Jim, Sylvester, Katharina, Hinz, Sonja, Matthey, Michaela, Wenzel, Daniela, Fleischmann, Bernd K., Pfeifer, Alexander, Inoue, Asuka, Gütschow, Michael, König, Gabriele M., Müller, Christa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070167/
https://www.ncbi.nlm.nih.gov/pubmed/31881095
http://dx.doi.org/10.1111/bph.14960

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