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Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation
BACKGROUND: Sex‐specific differences may influence prognosis after deferred revascularization following fractional flow reserve (FFR) measurement. This study sought to investigate the sex differences in long‐term prognosis of patients with deferred revascularization following FFR assessment. METHODS...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070212/ https://www.ncbi.nlm.nih.gov/pubmed/32063120 http://dx.doi.org/10.1161/JAHA.119.014458 |
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author | Hoshino, Masahiro Hamaya, Rikuta Kanaji, Yoshihisa Kanno, Yoshinori Hada, Masahiro Yamaguchi, Masao Sumino, Yohei Hirano, Hidenori Horie, Tomoki Usui, Eisuke Sugiyama, Tomoyo Murai, Tadashi Lee, Tetsumin Yonetsu, Taishi Lee, Joo Myung Choi, Ki Hong Hwang, Doyeon Park, Jonghanne Jung, Ji‐Hyun Kim, Hyung Yoon Jung, Hae Won Cho, Yun‐Kyeong Yoon, Hyuck‐Jun Song, Young Bin Hahn, Joo‐Yong Doh, Joon‐Hyung Nam, Chang‐Wook Shin, Eun‐Seok Hur, Seung‐Ho Mejía‐Rentería, Hernán Lauri, Francesco Goto, Sonoka Macaya, Fernando McInerney, Angela Gravina, Giacomo Vera, Rafael Gonzalo, Nieves Jimenez‐Quevedo, Pilar Nuñez‐Gil, Ivan Salinas, Pablo Nombela‐Franco, Luis del Trigo, Maria Fernández‐Ortiz, Antonio Macaya, Carlos Koo, Bon‐Kwon Escaned, Javier Kakuta, Tsunekazu |
author_facet | Hoshino, Masahiro Hamaya, Rikuta Kanaji, Yoshihisa Kanno, Yoshinori Hada, Masahiro Yamaguchi, Masao Sumino, Yohei Hirano, Hidenori Horie, Tomoki Usui, Eisuke Sugiyama, Tomoyo Murai, Tadashi Lee, Tetsumin Yonetsu, Taishi Lee, Joo Myung Choi, Ki Hong Hwang, Doyeon Park, Jonghanne Jung, Ji‐Hyun Kim, Hyung Yoon Jung, Hae Won Cho, Yun‐Kyeong Yoon, Hyuck‐Jun Song, Young Bin Hahn, Joo‐Yong Doh, Joon‐Hyung Nam, Chang‐Wook Shin, Eun‐Seok Hur, Seung‐Ho Mejía‐Rentería, Hernán Lauri, Francesco Goto, Sonoka Macaya, Fernando McInerney, Angela Gravina, Giacomo Vera, Rafael Gonzalo, Nieves Jimenez‐Quevedo, Pilar Nuñez‐Gil, Ivan Salinas, Pablo Nombela‐Franco, Luis del Trigo, Maria Fernández‐Ortiz, Antonio Macaya, Carlos Koo, Bon‐Kwon Escaned, Javier Kakuta, Tsunekazu |
author_sort | Hoshino, Masahiro |
collection | PubMed |
description | BACKGROUND: Sex‐specific differences may influence prognosis after deferred revascularization following fractional flow reserve (FFR) measurement. This study sought to investigate the sex differences in long‐term prognosis of patients with deferred revascularization following FFR assessment. METHODS AND RESULTS: A total of 879 patients (879 vessels) with deferred revascularization with FFR >0.75 who underwent FFR and coronary flow reserve measurements were enrolled from 3 countries (Korea, Japan, and Spain). Long‐term outcomes were assessed in 649 men and 230 women by the patient‐oriented composite outcome (POCO, a composite of any death, any myocardial infarction, and any revascularization). We applied inverse‐probability weighting based on propensity scores to account for differences at baseline between women and men (age, hyperlipidemia, diabetes mellitus, diameter stenosis, lesion length, multivessel disease, FFR, coronary flow reserve. The median follow‐up duration was 1855 days (745–1855 days). Median FFR values were 0.88 (0.83–0.93) in men and 0.89 (0.85–0.94) in women, respectively. The occurrences of POCO were significantly high in men compared with that in women (10.5% versus 4.2%, P=0.007). Kaplan–Meier analysis revealed that women had a significantly lower risk of POCO (χ(2)=7.2, P=0.007). Multivariate COX proportional hazards regression analysis revealed that age, male, diabetes mellitus, diameter stenosis, lesion length, and coronary flow reserve were independent predictors of POCO. After applying IPW, the hazard ratio of males for POCO was 2.07 (95% CI, 1.07–4.04, P=0.032). CONCLUSIONS: This large multinational study reveals that long‐term outcome differs between women and men in favor of women after FFR‐guided revascularization deferral. CLINICAL TRIAL REGISTRATION: URL: http://www.ClinicalTrials.gov. Unique identifier: NCT02186093. |
format | Online Article Text |
id | pubmed-7070212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70702122020-03-17 Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation Hoshino, Masahiro Hamaya, Rikuta Kanaji, Yoshihisa Kanno, Yoshinori Hada, Masahiro Yamaguchi, Masao Sumino, Yohei Hirano, Hidenori Horie, Tomoki Usui, Eisuke Sugiyama, Tomoyo Murai, Tadashi Lee, Tetsumin Yonetsu, Taishi Lee, Joo Myung Choi, Ki Hong Hwang, Doyeon Park, Jonghanne Jung, Ji‐Hyun Kim, Hyung Yoon Jung, Hae Won Cho, Yun‐Kyeong Yoon, Hyuck‐Jun Song, Young Bin Hahn, Joo‐Yong Doh, Joon‐Hyung Nam, Chang‐Wook Shin, Eun‐Seok Hur, Seung‐Ho Mejía‐Rentería, Hernán Lauri, Francesco Goto, Sonoka Macaya, Fernando McInerney, Angela Gravina, Giacomo Vera, Rafael Gonzalo, Nieves Jimenez‐Quevedo, Pilar Nuñez‐Gil, Ivan Salinas, Pablo Nombela‐Franco, Luis del Trigo, Maria Fernández‐Ortiz, Antonio Macaya, Carlos Koo, Bon‐Kwon Escaned, Javier Kakuta, Tsunekazu J Am Heart Assoc Go Red for Women Spotlight BACKGROUND: Sex‐specific differences may influence prognosis after deferred revascularization following fractional flow reserve (FFR) measurement. This study sought to investigate the sex differences in long‐term prognosis of patients with deferred revascularization following FFR assessment. METHODS AND RESULTS: A total of 879 patients (879 vessels) with deferred revascularization with FFR >0.75 who underwent FFR and coronary flow reserve measurements were enrolled from 3 countries (Korea, Japan, and Spain). Long‐term outcomes were assessed in 649 men and 230 women by the patient‐oriented composite outcome (POCO, a composite of any death, any myocardial infarction, and any revascularization). We applied inverse‐probability weighting based on propensity scores to account for differences at baseline between women and men (age, hyperlipidemia, diabetes mellitus, diameter stenosis, lesion length, multivessel disease, FFR, coronary flow reserve. The median follow‐up duration was 1855 days (745–1855 days). Median FFR values were 0.88 (0.83–0.93) in men and 0.89 (0.85–0.94) in women, respectively. The occurrences of POCO were significantly high in men compared with that in women (10.5% versus 4.2%, P=0.007). Kaplan–Meier analysis revealed that women had a significantly lower risk of POCO (χ(2)=7.2, P=0.007). Multivariate COX proportional hazards regression analysis revealed that age, male, diabetes mellitus, diameter stenosis, lesion length, and coronary flow reserve were independent predictors of POCO. After applying IPW, the hazard ratio of males for POCO was 2.07 (95% CI, 1.07–4.04, P=0.032). CONCLUSIONS: This large multinational study reveals that long‐term outcome differs between women and men in favor of women after FFR‐guided revascularization deferral. CLINICAL TRIAL REGISTRATION: URL: http://www.ClinicalTrials.gov. Unique identifier: NCT02186093. John Wiley and Sons Inc. 2020-02-17 /pmc/articles/PMC7070212/ /pubmed/32063120 http://dx.doi.org/10.1161/JAHA.119.014458 Text en © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Go Red for Women Spotlight Hoshino, Masahiro Hamaya, Rikuta Kanaji, Yoshihisa Kanno, Yoshinori Hada, Masahiro Yamaguchi, Masao Sumino, Yohei Hirano, Hidenori Horie, Tomoki Usui, Eisuke Sugiyama, Tomoyo Murai, Tadashi Lee, Tetsumin Yonetsu, Taishi Lee, Joo Myung Choi, Ki Hong Hwang, Doyeon Park, Jonghanne Jung, Ji‐Hyun Kim, Hyung Yoon Jung, Hae Won Cho, Yun‐Kyeong Yoon, Hyuck‐Jun Song, Young Bin Hahn, Joo‐Yong Doh, Joon‐Hyung Nam, Chang‐Wook Shin, Eun‐Seok Hur, Seung‐Ho Mejía‐Rentería, Hernán Lauri, Francesco Goto, Sonoka Macaya, Fernando McInerney, Angela Gravina, Giacomo Vera, Rafael Gonzalo, Nieves Jimenez‐Quevedo, Pilar Nuñez‐Gil, Ivan Salinas, Pablo Nombela‐Franco, Luis del Trigo, Maria Fernández‐Ortiz, Antonio Macaya, Carlos Koo, Bon‐Kwon Escaned, Javier Kakuta, Tsunekazu Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation |
title | Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation |
title_full | Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation |
title_fullStr | Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation |
title_full_unstemmed | Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation |
title_short | Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation |
title_sort | sex differences in long‐term outcomes in patients with deferred revascularization following fractional flow reserve assessment: international collaboration registry of comprehensive physiologic evaluation |
topic | Go Red for Women Spotlight |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070212/ https://www.ncbi.nlm.nih.gov/pubmed/32063120 http://dx.doi.org/10.1161/JAHA.119.014458 |
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