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Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation

BACKGROUND: Sex‐specific differences may influence prognosis after deferred revascularization following fractional flow reserve (FFR) measurement. This study sought to investigate the sex differences in long‐term prognosis of patients with deferred revascularization following FFR assessment. METHODS...

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Autores principales: Hoshino, Masahiro, Hamaya, Rikuta, Kanaji, Yoshihisa, Kanno, Yoshinori, Hada, Masahiro, Yamaguchi, Masao, Sumino, Yohei, Hirano, Hidenori, Horie, Tomoki, Usui, Eisuke, Sugiyama, Tomoyo, Murai, Tadashi, Lee, Tetsumin, Yonetsu, Taishi, Lee, Joo Myung, Choi, Ki Hong, Hwang, Doyeon, Park, Jonghanne, Jung, Ji‐Hyun, Kim, Hyung Yoon, Jung, Hae Won, Cho, Yun‐Kyeong, Yoon, Hyuck‐Jun, Song, Young Bin, Hahn, Joo‐Yong, Doh, Joon‐Hyung, Nam, Chang‐Wook, Shin, Eun‐Seok, Hur, Seung‐Ho, Mejía‐Rentería, Hernán, Lauri, Francesco, Goto, Sonoka, Macaya, Fernando, McInerney, Angela, Gravina, Giacomo, Vera, Rafael, Gonzalo, Nieves, Jimenez‐Quevedo, Pilar, Nuñez‐Gil, Ivan, Salinas, Pablo, Nombela‐Franco, Luis, del Trigo, Maria, Fernández‐Ortiz, Antonio, Macaya, Carlos, Koo, Bon‐Kwon, Escaned, Javier, Kakuta, Tsunekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070212/
https://www.ncbi.nlm.nih.gov/pubmed/32063120
http://dx.doi.org/10.1161/JAHA.119.014458
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author Hoshino, Masahiro
Hamaya, Rikuta
Kanaji, Yoshihisa
Kanno, Yoshinori
Hada, Masahiro
Yamaguchi, Masao
Sumino, Yohei
Hirano, Hidenori
Horie, Tomoki
Usui, Eisuke
Sugiyama, Tomoyo
Murai, Tadashi
Lee, Tetsumin
Yonetsu, Taishi
Lee, Joo Myung
Choi, Ki Hong
Hwang, Doyeon
Park, Jonghanne
Jung, Ji‐Hyun
Kim, Hyung Yoon
Jung, Hae Won
Cho, Yun‐Kyeong
Yoon, Hyuck‐Jun
Song, Young Bin
Hahn, Joo‐Yong
Doh, Joon‐Hyung
Nam, Chang‐Wook
Shin, Eun‐Seok
Hur, Seung‐Ho
Mejía‐Rentería, Hernán
Lauri, Francesco
Goto, Sonoka
Macaya, Fernando
McInerney, Angela
Gravina, Giacomo
Vera, Rafael
Gonzalo, Nieves
Jimenez‐Quevedo, Pilar
Nuñez‐Gil, Ivan
Salinas, Pablo
Nombela‐Franco, Luis
del Trigo, Maria
Fernández‐Ortiz, Antonio
Macaya, Carlos
Koo, Bon‐Kwon
Escaned, Javier
Kakuta, Tsunekazu
author_facet Hoshino, Masahiro
Hamaya, Rikuta
Kanaji, Yoshihisa
Kanno, Yoshinori
Hada, Masahiro
Yamaguchi, Masao
Sumino, Yohei
Hirano, Hidenori
Horie, Tomoki
Usui, Eisuke
Sugiyama, Tomoyo
Murai, Tadashi
Lee, Tetsumin
Yonetsu, Taishi
Lee, Joo Myung
Choi, Ki Hong
Hwang, Doyeon
Park, Jonghanne
Jung, Ji‐Hyun
Kim, Hyung Yoon
Jung, Hae Won
Cho, Yun‐Kyeong
Yoon, Hyuck‐Jun
Song, Young Bin
Hahn, Joo‐Yong
Doh, Joon‐Hyung
Nam, Chang‐Wook
Shin, Eun‐Seok
Hur, Seung‐Ho
Mejía‐Rentería, Hernán
Lauri, Francesco
Goto, Sonoka
Macaya, Fernando
McInerney, Angela
Gravina, Giacomo
Vera, Rafael
Gonzalo, Nieves
Jimenez‐Quevedo, Pilar
Nuñez‐Gil, Ivan
Salinas, Pablo
Nombela‐Franco, Luis
del Trigo, Maria
Fernández‐Ortiz, Antonio
Macaya, Carlos
Koo, Bon‐Kwon
Escaned, Javier
Kakuta, Tsunekazu
author_sort Hoshino, Masahiro
collection PubMed
description BACKGROUND: Sex‐specific differences may influence prognosis after deferred revascularization following fractional flow reserve (FFR) measurement. This study sought to investigate the sex differences in long‐term prognosis of patients with deferred revascularization following FFR assessment. METHODS AND RESULTS: A total of 879 patients (879 vessels) with deferred revascularization with FFR >0.75 who underwent FFR and coronary flow reserve measurements were enrolled from 3 countries (Korea, Japan, and Spain). Long‐term outcomes were assessed in 649 men and 230 women by the patient‐oriented composite outcome (POCO, a composite of any death, any myocardial infarction, and any revascularization). We applied inverse‐probability weighting based on propensity scores to account for differences at baseline between women and men (age, hyperlipidemia, diabetes mellitus, diameter stenosis, lesion length, multivessel disease, FFR, coronary flow reserve. The median follow‐up duration was 1855 days (745–1855 days). Median FFR values were 0.88 (0.83–0.93) in men and 0.89 (0.85–0.94) in women, respectively. The occurrences of POCO were significantly high in men compared with that in women (10.5% versus 4.2%, P=0.007). Kaplan–Meier analysis revealed that women had a significantly lower risk of POCO (χ(2)=7.2, P=0.007). Multivariate COX proportional hazards regression analysis revealed that age, male, diabetes mellitus, diameter stenosis, lesion length, and coronary flow reserve were independent predictors of POCO. After applying IPW, the hazard ratio of males for POCO was 2.07 (95% CI, 1.07–4.04, P=0.032). CONCLUSIONS: This large multinational study reveals that long‐term outcome differs between women and men in favor of women after FFR‐guided revascularization deferral. CLINICAL TRIAL REGISTRATION: URL: http://www.ClinicalTrials.gov. Unique identifier: NCT02186093.
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spelling pubmed-70702122020-03-17 Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation Hoshino, Masahiro Hamaya, Rikuta Kanaji, Yoshihisa Kanno, Yoshinori Hada, Masahiro Yamaguchi, Masao Sumino, Yohei Hirano, Hidenori Horie, Tomoki Usui, Eisuke Sugiyama, Tomoyo Murai, Tadashi Lee, Tetsumin Yonetsu, Taishi Lee, Joo Myung Choi, Ki Hong Hwang, Doyeon Park, Jonghanne Jung, Ji‐Hyun Kim, Hyung Yoon Jung, Hae Won Cho, Yun‐Kyeong Yoon, Hyuck‐Jun Song, Young Bin Hahn, Joo‐Yong Doh, Joon‐Hyung Nam, Chang‐Wook Shin, Eun‐Seok Hur, Seung‐Ho Mejía‐Rentería, Hernán Lauri, Francesco Goto, Sonoka Macaya, Fernando McInerney, Angela Gravina, Giacomo Vera, Rafael Gonzalo, Nieves Jimenez‐Quevedo, Pilar Nuñez‐Gil, Ivan Salinas, Pablo Nombela‐Franco, Luis del Trigo, Maria Fernández‐Ortiz, Antonio Macaya, Carlos Koo, Bon‐Kwon Escaned, Javier Kakuta, Tsunekazu J Am Heart Assoc Go Red for Women Spotlight BACKGROUND: Sex‐specific differences may influence prognosis after deferred revascularization following fractional flow reserve (FFR) measurement. This study sought to investigate the sex differences in long‐term prognosis of patients with deferred revascularization following FFR assessment. METHODS AND RESULTS: A total of 879 patients (879 vessels) with deferred revascularization with FFR >0.75 who underwent FFR and coronary flow reserve measurements were enrolled from 3 countries (Korea, Japan, and Spain). Long‐term outcomes were assessed in 649 men and 230 women by the patient‐oriented composite outcome (POCO, a composite of any death, any myocardial infarction, and any revascularization). We applied inverse‐probability weighting based on propensity scores to account for differences at baseline between women and men (age, hyperlipidemia, diabetes mellitus, diameter stenosis, lesion length, multivessel disease, FFR, coronary flow reserve. The median follow‐up duration was 1855 days (745–1855 days). Median FFR values were 0.88 (0.83–0.93) in men and 0.89 (0.85–0.94) in women, respectively. The occurrences of POCO were significantly high in men compared with that in women (10.5% versus 4.2%, P=0.007). Kaplan–Meier analysis revealed that women had a significantly lower risk of POCO (χ(2)=7.2, P=0.007). Multivariate COX proportional hazards regression analysis revealed that age, male, diabetes mellitus, diameter stenosis, lesion length, and coronary flow reserve were independent predictors of POCO. After applying IPW, the hazard ratio of males for POCO was 2.07 (95% CI, 1.07–4.04, P=0.032). CONCLUSIONS: This large multinational study reveals that long‐term outcome differs between women and men in favor of women after FFR‐guided revascularization deferral. CLINICAL TRIAL REGISTRATION: URL: http://www.ClinicalTrials.gov. Unique identifier: NCT02186093. John Wiley and Sons Inc. 2020-02-17 /pmc/articles/PMC7070212/ /pubmed/32063120 http://dx.doi.org/10.1161/JAHA.119.014458 Text en © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Go Red for Women Spotlight
Hoshino, Masahiro
Hamaya, Rikuta
Kanaji, Yoshihisa
Kanno, Yoshinori
Hada, Masahiro
Yamaguchi, Masao
Sumino, Yohei
Hirano, Hidenori
Horie, Tomoki
Usui, Eisuke
Sugiyama, Tomoyo
Murai, Tadashi
Lee, Tetsumin
Yonetsu, Taishi
Lee, Joo Myung
Choi, Ki Hong
Hwang, Doyeon
Park, Jonghanne
Jung, Ji‐Hyun
Kim, Hyung Yoon
Jung, Hae Won
Cho, Yun‐Kyeong
Yoon, Hyuck‐Jun
Song, Young Bin
Hahn, Joo‐Yong
Doh, Joon‐Hyung
Nam, Chang‐Wook
Shin, Eun‐Seok
Hur, Seung‐Ho
Mejía‐Rentería, Hernán
Lauri, Francesco
Goto, Sonoka
Macaya, Fernando
McInerney, Angela
Gravina, Giacomo
Vera, Rafael
Gonzalo, Nieves
Jimenez‐Quevedo, Pilar
Nuñez‐Gil, Ivan
Salinas, Pablo
Nombela‐Franco, Luis
del Trigo, Maria
Fernández‐Ortiz, Antonio
Macaya, Carlos
Koo, Bon‐Kwon
Escaned, Javier
Kakuta, Tsunekazu
Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation
title Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation
title_full Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation
title_fullStr Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation
title_full_unstemmed Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation
title_short Sex Differences in Long‐Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation
title_sort sex differences in long‐term outcomes in patients with deferred revascularization following fractional flow reserve assessment: international collaboration registry of comprehensive physiologic evaluation
topic Go Red for Women Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070212/
https://www.ncbi.nlm.nih.gov/pubmed/32063120
http://dx.doi.org/10.1161/JAHA.119.014458
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