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Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children

In this study, the levels of concentration of homocysteine thiolactone (HTL), cysteine (Cys), and cysteinylglycine (CysGly) in the urine of autistic and non-autistic children were investigated and compared. HTL has never been analyzed in autistic children. The levels of low molecular weight sulfur c...

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Autores principales: Gątarek, Paulina, Rosiak, Angelina, Borowczyk, Kamila, Głowacki, Rafał, Kałużna-Czaplińska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070266/
https://www.ncbi.nlm.nih.gov/pubmed/32098164
http://dx.doi.org/10.3390/molecules25040973
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author Gątarek, Paulina
Rosiak, Angelina
Borowczyk, Kamila
Głowacki, Rafał
Kałużna-Czaplińska, Joanna
author_facet Gątarek, Paulina
Rosiak, Angelina
Borowczyk, Kamila
Głowacki, Rafał
Kałużna-Czaplińska, Joanna
author_sort Gątarek, Paulina
collection PubMed
description In this study, the levels of concentration of homocysteine thiolactone (HTL), cysteine (Cys), and cysteinylglycine (CysGly) in the urine of autistic and non-autistic children were investigated and compared. HTL has never been analyzed in autistic children. The levels of low molecular weight sulfur compounds in the urine of both groups were determined by validated methods based on high-performance liquid chromatography with spectrofluorometric and diode-array detectors. The statistical data show a significant difference between the examined groups. Children with autism were characterized by a significantly higher level of HTL (p = 5.86 × 10(−8)), Cys (p = 1.49 × 10(−10)) and CysGly (p = 1.06 × 10(−8)) in urine compared with the control group. A difference in the p-value of <0.05 is statistically significant. Higher levels of HTL, Cys, and CysGly in the urine of 41 children with autism, aged 3 to 17, were observed. The obtained results may indicate disturbances in the metabolism of methionine, Cys, and glutathione in some autistic patients. These preliminary results suggest that further research with more rigorous designs and a large number of subjects is needed.
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spelling pubmed-70702662020-03-19 Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children Gątarek, Paulina Rosiak, Angelina Borowczyk, Kamila Głowacki, Rafał Kałużna-Czaplińska, Joanna Molecules Article In this study, the levels of concentration of homocysteine thiolactone (HTL), cysteine (Cys), and cysteinylglycine (CysGly) in the urine of autistic and non-autistic children were investigated and compared. HTL has never been analyzed in autistic children. The levels of low molecular weight sulfur compounds in the urine of both groups were determined by validated methods based on high-performance liquid chromatography with spectrofluorometric and diode-array detectors. The statistical data show a significant difference between the examined groups. Children with autism were characterized by a significantly higher level of HTL (p = 5.86 × 10(−8)), Cys (p = 1.49 × 10(−10)) and CysGly (p = 1.06 × 10(−8)) in urine compared with the control group. A difference in the p-value of <0.05 is statistically significant. Higher levels of HTL, Cys, and CysGly in the urine of 41 children with autism, aged 3 to 17, were observed. The obtained results may indicate disturbances in the metabolism of methionine, Cys, and glutathione in some autistic patients. These preliminary results suggest that further research with more rigorous designs and a large number of subjects is needed. MDPI 2020-02-21 /pmc/articles/PMC7070266/ /pubmed/32098164 http://dx.doi.org/10.3390/molecules25040973 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gątarek, Paulina
Rosiak, Angelina
Borowczyk, Kamila
Głowacki, Rafał
Kałużna-Czaplińska, Joanna
Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children
title Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children
title_full Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children
title_fullStr Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children
title_full_unstemmed Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children
title_short Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children
title_sort higher levels of low molecular weight sulfur compounds and homocysteine thiolactone in the urine of autistic children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070266/
https://www.ncbi.nlm.nih.gov/pubmed/32098164
http://dx.doi.org/10.3390/molecules25040973
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