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Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children
In this study, the levels of concentration of homocysteine thiolactone (HTL), cysteine (Cys), and cysteinylglycine (CysGly) in the urine of autistic and non-autistic children were investigated and compared. HTL has never been analyzed in autistic children. The levels of low molecular weight sulfur c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070266/ https://www.ncbi.nlm.nih.gov/pubmed/32098164 http://dx.doi.org/10.3390/molecules25040973 |
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author | Gątarek, Paulina Rosiak, Angelina Borowczyk, Kamila Głowacki, Rafał Kałużna-Czaplińska, Joanna |
author_facet | Gątarek, Paulina Rosiak, Angelina Borowczyk, Kamila Głowacki, Rafał Kałużna-Czaplińska, Joanna |
author_sort | Gątarek, Paulina |
collection | PubMed |
description | In this study, the levels of concentration of homocysteine thiolactone (HTL), cysteine (Cys), and cysteinylglycine (CysGly) in the urine of autistic and non-autistic children were investigated and compared. HTL has never been analyzed in autistic children. The levels of low molecular weight sulfur compounds in the urine of both groups were determined by validated methods based on high-performance liquid chromatography with spectrofluorometric and diode-array detectors. The statistical data show a significant difference between the examined groups. Children with autism were characterized by a significantly higher level of HTL (p = 5.86 × 10(−8)), Cys (p = 1.49 × 10(−10)) and CysGly (p = 1.06 × 10(−8)) in urine compared with the control group. A difference in the p-value of <0.05 is statistically significant. Higher levels of HTL, Cys, and CysGly in the urine of 41 children with autism, aged 3 to 17, were observed. The obtained results may indicate disturbances in the metabolism of methionine, Cys, and glutathione in some autistic patients. These preliminary results suggest that further research with more rigorous designs and a large number of subjects is needed. |
format | Online Article Text |
id | pubmed-7070266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70702662020-03-19 Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children Gątarek, Paulina Rosiak, Angelina Borowczyk, Kamila Głowacki, Rafał Kałużna-Czaplińska, Joanna Molecules Article In this study, the levels of concentration of homocysteine thiolactone (HTL), cysteine (Cys), and cysteinylglycine (CysGly) in the urine of autistic and non-autistic children were investigated and compared. HTL has never been analyzed in autistic children. The levels of low molecular weight sulfur compounds in the urine of both groups were determined by validated methods based on high-performance liquid chromatography with spectrofluorometric and diode-array detectors. The statistical data show a significant difference between the examined groups. Children with autism were characterized by a significantly higher level of HTL (p = 5.86 × 10(−8)), Cys (p = 1.49 × 10(−10)) and CysGly (p = 1.06 × 10(−8)) in urine compared with the control group. A difference in the p-value of <0.05 is statistically significant. Higher levels of HTL, Cys, and CysGly in the urine of 41 children with autism, aged 3 to 17, were observed. The obtained results may indicate disturbances in the metabolism of methionine, Cys, and glutathione in some autistic patients. These preliminary results suggest that further research with more rigorous designs and a large number of subjects is needed. MDPI 2020-02-21 /pmc/articles/PMC7070266/ /pubmed/32098164 http://dx.doi.org/10.3390/molecules25040973 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gątarek, Paulina Rosiak, Angelina Borowczyk, Kamila Głowacki, Rafał Kałużna-Czaplińska, Joanna Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children |
title | Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children |
title_full | Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children |
title_fullStr | Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children |
title_full_unstemmed | Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children |
title_short | Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children |
title_sort | higher levels of low molecular weight sulfur compounds and homocysteine thiolactone in the urine of autistic children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070266/ https://www.ncbi.nlm.nih.gov/pubmed/32098164 http://dx.doi.org/10.3390/molecules25040973 |
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