Discovery of 9O-Substituted Palmatine Derivatives as a New Class of Anti-COL1A1 Agents Via Repressing TGF-β1/Smads and JAK1/STAT3 Pathways

Twenty 9O-substituted palmatine derivatives were prepared and tested for their biological effect against collagen α1 (I) (COL1A1) promotor in human hepatic stellate LX-2 cells. The structure−activity relationship (SAR) indicated that the introduction of a benzyl motif on the 9O atom was favorable fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Fan, Tianyun, Ge, Maoxu, Guo, Zhihao, He, Hongwei, Zhang, Na, Li, Yinghong, Song, Danqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070350/
https://www.ncbi.nlm.nih.gov/pubmed/32054011
http://dx.doi.org/10.3390/molecules25040773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070350/
https://www.ncbi.nlm.nih.gov/pubmed/32054011
http://dx.doi.org/10.3390/molecules25040773

Ejemplares similares