Regioselective Monobromination of Phenols with KBr and ZnAl–BrO(3)(−)–Layered Double Hydroxides

The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl–BrO(3)(−)–layered double hydroxides (abbreviated as ZnAl–BrO(3)(−)–LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reac...

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Detalles Bibliográficos
Autores principales: Wang, Ligeng, Feng, Chun, Zhang, Yan, Hu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070364/
https://www.ncbi.nlm.nih.gov/pubmed/32085603
http://dx.doi.org/10.3390/molecules25040914
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author Wang, Ligeng
Feng, Chun
Zhang, Yan
Hu, Jun
author_facet Wang, Ligeng
Feng, Chun
Zhang, Yan
Hu, Jun
author_sort Wang, Ligeng
collection PubMed
description The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl–BrO(3)(−)–layered double hydroxides (abbreviated as ZnAl–BrO(3)(−)–LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reaction featured with excellent regioselectivity, cheap brominating reagents, mild reaction condition, high atom economy, broad substrate scope, and provided an efficient method to synthesize bromophenols.
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spelling pubmed-70703642020-03-19 Regioselective Monobromination of Phenols with KBr and ZnAl–BrO(3)(−)–Layered Double Hydroxides Wang, Ligeng Feng, Chun Zhang, Yan Hu, Jun Molecules Communication The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl–BrO(3)(−)–layered double hydroxides (abbreviated as ZnAl–BrO(3)(−)–LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reaction featured with excellent regioselectivity, cheap brominating reagents, mild reaction condition, high atom economy, broad substrate scope, and provided an efficient method to synthesize bromophenols. MDPI 2020-02-18 /pmc/articles/PMC7070364/ /pubmed/32085603 http://dx.doi.org/10.3390/molecules25040914 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Wang, Ligeng
Feng, Chun
Zhang, Yan
Hu, Jun
Regioselective Monobromination of Phenols with KBr and ZnAl–BrO(3)(−)–Layered Double Hydroxides
title Regioselective Monobromination of Phenols with KBr and ZnAl–BrO(3)(−)–Layered Double Hydroxides
title_full Regioselective Monobromination of Phenols with KBr and ZnAl–BrO(3)(−)–Layered Double Hydroxides
title_fullStr Regioselective Monobromination of Phenols with KBr and ZnAl–BrO(3)(−)–Layered Double Hydroxides
title_full_unstemmed Regioselective Monobromination of Phenols with KBr and ZnAl–BrO(3)(−)–Layered Double Hydroxides
title_short Regioselective Monobromination of Phenols with KBr and ZnAl–BrO(3)(−)–Layered Double Hydroxides
title_sort regioselective monobromination of phenols with kbr and znal–bro(3)(−)–layered double hydroxides
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070364/
https://www.ncbi.nlm.nih.gov/pubmed/32085603
http://dx.doi.org/10.3390/molecules25040914
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