Cargando…

P-TEFb as A Promising Therapeutic Target

The positive transcription elongation factor b (P-TEFb) was first identified as a general factor that stimulates transcription elongation by RNA polymerase II (RNAPII), but soon afterwards it turned out to be an essential cellular co-factor of human immunodeficiency virus (HIV) transcription mediate...

Descripción completa

Detalles Bibliográficos
Autor principal: Fujinaga, Koh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070488/
https://www.ncbi.nlm.nih.gov/pubmed/32075058
http://dx.doi.org/10.3390/molecules25040838
_version_ 1783505986914353152
author Fujinaga, Koh
author_facet Fujinaga, Koh
author_sort Fujinaga, Koh
collection PubMed
description The positive transcription elongation factor b (P-TEFb) was first identified as a general factor that stimulates transcription elongation by RNA polymerase II (RNAPII), but soon afterwards it turned out to be an essential cellular co-factor of human immunodeficiency virus (HIV) transcription mediated by viral Tat proteins. Studies on the mechanisms of Tat-dependent HIV transcription have led to radical advances in our knowledge regarding the mechanism of eukaryotic transcription, including the discoveries that P-TEFb-mediated elongation control of cellular transcription is a main regulatory step of gene expression in eukaryotes, and deregulation of P-TEFb activity plays critical roles in many human diseases and conditions in addition to HIV/AIDS. P-TEFb is now recognized as an attractive and promising therapeutic target for inflammation/autoimmune diseases, cardiac hypertrophy, cancer, infectious diseases, etc. In this review article, I will summarize our knowledge about basic P-TEFb functions, the regulatory mechanism of P-TEFb-dependent transcription, P-TEFb’s involvement in biological processes and diseases, and current approaches to manipulating P-TEFb functions for the treatment of these diseases.
format Online
Article
Text
id pubmed-7070488
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70704882020-03-19 P-TEFb as A Promising Therapeutic Target Fujinaga, Koh Molecules Review The positive transcription elongation factor b (P-TEFb) was first identified as a general factor that stimulates transcription elongation by RNA polymerase II (RNAPII), but soon afterwards it turned out to be an essential cellular co-factor of human immunodeficiency virus (HIV) transcription mediated by viral Tat proteins. Studies on the mechanisms of Tat-dependent HIV transcription have led to radical advances in our knowledge regarding the mechanism of eukaryotic transcription, including the discoveries that P-TEFb-mediated elongation control of cellular transcription is a main regulatory step of gene expression in eukaryotes, and deregulation of P-TEFb activity plays critical roles in many human diseases and conditions in addition to HIV/AIDS. P-TEFb is now recognized as an attractive and promising therapeutic target for inflammation/autoimmune diseases, cardiac hypertrophy, cancer, infectious diseases, etc. In this review article, I will summarize our knowledge about basic P-TEFb functions, the regulatory mechanism of P-TEFb-dependent transcription, P-TEFb’s involvement in biological processes and diseases, and current approaches to manipulating P-TEFb functions for the treatment of these diseases. MDPI 2020-02-14 /pmc/articles/PMC7070488/ /pubmed/32075058 http://dx.doi.org/10.3390/molecules25040838 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fujinaga, Koh
P-TEFb as A Promising Therapeutic Target
title P-TEFb as A Promising Therapeutic Target
title_full P-TEFb as A Promising Therapeutic Target
title_fullStr P-TEFb as A Promising Therapeutic Target
title_full_unstemmed P-TEFb as A Promising Therapeutic Target
title_short P-TEFb as A Promising Therapeutic Target
title_sort p-tefb as a promising therapeutic target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070488/
https://www.ncbi.nlm.nih.gov/pubmed/32075058
http://dx.doi.org/10.3390/molecules25040838
work_keys_str_mv AT fujinagakoh ptefbasapromisingtherapeutictarget