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Flow Synthesis of Biologically-Relevant Compound Libraries

Flow chemistry is one of the most prominent enabling technologies that has greatly shaped the way chemists’ approach organic synthesis. Specifically, in drug discovery, the advantages of flow techniques over batch procedures allow the rapid and efficient assembly of compound libraries to be tested f...

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Detalles Bibliográficos
Autores principales: Luque Navarro, Pilar María, Lanari, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070499/
https://www.ncbi.nlm.nih.gov/pubmed/32085549
http://dx.doi.org/10.3390/molecules25040909
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author Luque Navarro, Pilar María
Lanari, Daniela
author_facet Luque Navarro, Pilar María
Lanari, Daniela
author_sort Luque Navarro, Pilar María
collection PubMed
description Flow chemistry is one of the most prominent enabling technologies that has greatly shaped the way chemists’ approach organic synthesis. Specifically, in drug discovery, the advantages of flow techniques over batch procedures allow the rapid and efficient assembly of compound libraries to be tested for biological properties. The aim of the present review is to comment on some representative examples from the last five years of literature that highlight how flow procedures are becoming of increasing importance for the synthesis of biologically-relevant molecules.
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spelling pubmed-70704992020-03-19 Flow Synthesis of Biologically-Relevant Compound Libraries Luque Navarro, Pilar María Lanari, Daniela Molecules Review Flow chemistry is one of the most prominent enabling technologies that has greatly shaped the way chemists’ approach organic synthesis. Specifically, in drug discovery, the advantages of flow techniques over batch procedures allow the rapid and efficient assembly of compound libraries to be tested for biological properties. The aim of the present review is to comment on some representative examples from the last five years of literature that highlight how flow procedures are becoming of increasing importance for the synthesis of biologically-relevant molecules. MDPI 2020-02-18 /pmc/articles/PMC7070499/ /pubmed/32085549 http://dx.doi.org/10.3390/molecules25040909 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Luque Navarro, Pilar María
Lanari, Daniela
Flow Synthesis of Biologically-Relevant Compound Libraries
title Flow Synthesis of Biologically-Relevant Compound Libraries
title_full Flow Synthesis of Biologically-Relevant Compound Libraries
title_fullStr Flow Synthesis of Biologically-Relevant Compound Libraries
title_full_unstemmed Flow Synthesis of Biologically-Relevant Compound Libraries
title_short Flow Synthesis of Biologically-Relevant Compound Libraries
title_sort flow synthesis of biologically-relevant compound libraries
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070499/
https://www.ncbi.nlm.nih.gov/pubmed/32085549
http://dx.doi.org/10.3390/molecules25040909
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