Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity

Biology is dominated by polyanions (cell membranes, nucleic acids, and polysaccharides just to name a few), and achieving selective recognition between biological polyanions and synthetic systems currently constitutes a major challenge in many biomedical applications, nanovectors-assisted gene deliv...

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Detalles Bibliográficos
Autores principales: Marson, Domenico, Laurini, Erik, Aulic, Suzana, Fermeglia, Maurizio, Pricl, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070608/
https://www.ncbi.nlm.nih.gov/pubmed/32102359
http://dx.doi.org/10.3390/molecules25041003
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author Marson, Domenico
Laurini, Erik
Aulic, Suzana
Fermeglia, Maurizio
Pricl, Sabrina
author_facet Marson, Domenico
Laurini, Erik
Aulic, Suzana
Fermeglia, Maurizio
Pricl, Sabrina
author_sort Marson, Domenico
collection PubMed
description Biology is dominated by polyanions (cell membranes, nucleic acids, and polysaccharides just to name a few), and achieving selective recognition between biological polyanions and synthetic systems currently constitutes a major challenge in many biomedical applications, nanovectors-assisted gene delivery being a prime example. This review work summarizes some of our recent efforts in this field; in particular, by using a combined experimental/computation approach, we investigated in detail some critical aspects in self-assembled nanomicelles and two major polyanions—DNA and heparin.
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spelling pubmed-70706082020-03-19 Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity Marson, Domenico Laurini, Erik Aulic, Suzana Fermeglia, Maurizio Pricl, Sabrina Molecules Review Biology is dominated by polyanions (cell membranes, nucleic acids, and polysaccharides just to name a few), and achieving selective recognition between biological polyanions and synthetic systems currently constitutes a major challenge in many biomedical applications, nanovectors-assisted gene delivery being a prime example. This review work summarizes some of our recent efforts in this field; in particular, by using a combined experimental/computation approach, we investigated in detail some critical aspects in self-assembled nanomicelles and two major polyanions—DNA and heparin. MDPI 2020-02-24 /pmc/articles/PMC7070608/ /pubmed/32102359 http://dx.doi.org/10.3390/molecules25041003 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Marson, Domenico
Laurini, Erik
Aulic, Suzana
Fermeglia, Maurizio
Pricl, Sabrina
Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity
title Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity
title_full Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity
title_fullStr Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity
title_full_unstemmed Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity
title_short Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity
title_sort perceptions and misconceptions in molecular recognition: key factors in self-assembling multivalent (samul) ligands/polyanions selectivity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070608/
https://www.ncbi.nlm.nih.gov/pubmed/32102359
http://dx.doi.org/10.3390/molecules25041003
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