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Effects of Dietary Supplementation with Combination of Tributyrin and Essential Oil on Gut Health and Microbiota of Weaned Piglets

SIMPLE SUMMARY: The dietary inclusion of the combination of tributyrin with either oregano or methyl salicylate as a substitution to antibiotics improved intestinal morphological structure of weaned piglets and resulted in major changes in the profiles of intestine microbiota and metabolites, which...

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Autores principales: Zhang, Wen-Xin, Zhang, Yu, Zhang, Xiao-Wei, Deng, Zhao-Xi, Liu, Jian-Xin, He, Mao-Long, Wang, Hai-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070613/
https://www.ncbi.nlm.nih.gov/pubmed/31973120
http://dx.doi.org/10.3390/ani10020180
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author Zhang, Wen-Xin
Zhang, Yu
Zhang, Xiao-Wei
Deng, Zhao-Xi
Liu, Jian-Xin
He, Mao-Long
Wang, Hai-Feng
author_facet Zhang, Wen-Xin
Zhang, Yu
Zhang, Xiao-Wei
Deng, Zhao-Xi
Liu, Jian-Xin
He, Mao-Long
Wang, Hai-Feng
author_sort Zhang, Wen-Xin
collection PubMed
description SIMPLE SUMMARY: The dietary inclusion of the combination of tributyrin with either oregano or methyl salicylate as a substitution to antibiotics improved intestinal morphological structure of weaned piglets and resulted in major changes in the profiles of intestine microbiota and metabolites, which exerted beneficial effects on intestinal health of piglets. Our study indicated that the combination of tributyrate with oregano or methyl salicylate could be used as an alternative feed additive to the antibiotics. ABSTRACT: The aim of this study was to determine the effects of dietary inclusion of the combination of tributyrin with oregano or methyl salicylate as a substitute to antibiotics on gut health and microbiota of piglets. A total of 48 weaned crossbred piglets (Duroc × Large White × Landrace, 8.79 ± 0.97 kg, 21 ± 1 d) were randomly allocated to four experimental groups and fed for 4 weeks: the basal diet (Con); the control plus antibiotics (AB); the control plus oregano and tributyrin (OT); and the control plus methyl salicylate and tributyrin (MT). Although a numerical improvement on feed intake, weight gain and feed conversion ratio was observed in the OT and MT as well as the AB group, the difference was not significant (p > 0.05). The OT and MT groups were larger in villus height in the duodenum compared to the Con (p < 0.05), and were larger in relative abundance of Firmicutes/Bacaeroides in the intestine compared to Con and AB groups (p < 0.01). The amount of major different metabolites was 6, 8 and 8 for the AB, OT and MT groups when compared to the Con, respectively. In conclusion, as a substitute for antibiotics the inclusion of the combination of tributyrin with either oregano or methyl salicylate to the diet of weaned piglets improved the intestinal morphological structure and altered intestinal microbiota and metabolites, which were beneficial to the animal health.
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spelling pubmed-70706132020-03-19 Effects of Dietary Supplementation with Combination of Tributyrin and Essential Oil on Gut Health and Microbiota of Weaned Piglets Zhang, Wen-Xin Zhang, Yu Zhang, Xiao-Wei Deng, Zhao-Xi Liu, Jian-Xin He, Mao-Long Wang, Hai-Feng Animals (Basel) Article SIMPLE SUMMARY: The dietary inclusion of the combination of tributyrin with either oregano or methyl salicylate as a substitution to antibiotics improved intestinal morphological structure of weaned piglets and resulted in major changes in the profiles of intestine microbiota and metabolites, which exerted beneficial effects on intestinal health of piglets. Our study indicated that the combination of tributyrate with oregano or methyl salicylate could be used as an alternative feed additive to the antibiotics. ABSTRACT: The aim of this study was to determine the effects of dietary inclusion of the combination of tributyrin with oregano or methyl salicylate as a substitute to antibiotics on gut health and microbiota of piglets. A total of 48 weaned crossbred piglets (Duroc × Large White × Landrace, 8.79 ± 0.97 kg, 21 ± 1 d) were randomly allocated to four experimental groups and fed for 4 weeks: the basal diet (Con); the control plus antibiotics (AB); the control plus oregano and tributyrin (OT); and the control plus methyl salicylate and tributyrin (MT). Although a numerical improvement on feed intake, weight gain and feed conversion ratio was observed in the OT and MT as well as the AB group, the difference was not significant (p > 0.05). The OT and MT groups were larger in villus height in the duodenum compared to the Con (p < 0.05), and were larger in relative abundance of Firmicutes/Bacaeroides in the intestine compared to Con and AB groups (p < 0.01). The amount of major different metabolites was 6, 8 and 8 for the AB, OT and MT groups when compared to the Con, respectively. In conclusion, as a substitute for antibiotics the inclusion of the combination of tributyrin with either oregano or methyl salicylate to the diet of weaned piglets improved the intestinal morphological structure and altered intestinal microbiota and metabolites, which were beneficial to the animal health. MDPI 2020-01-21 /pmc/articles/PMC7070613/ /pubmed/31973120 http://dx.doi.org/10.3390/ani10020180 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Wen-Xin
Zhang, Yu
Zhang, Xiao-Wei
Deng, Zhao-Xi
Liu, Jian-Xin
He, Mao-Long
Wang, Hai-Feng
Effects of Dietary Supplementation with Combination of Tributyrin and Essential Oil on Gut Health and Microbiota of Weaned Piglets
title Effects of Dietary Supplementation with Combination of Tributyrin and Essential Oil on Gut Health and Microbiota of Weaned Piglets
title_full Effects of Dietary Supplementation with Combination of Tributyrin and Essential Oil on Gut Health and Microbiota of Weaned Piglets
title_fullStr Effects of Dietary Supplementation with Combination of Tributyrin and Essential Oil on Gut Health and Microbiota of Weaned Piglets
title_full_unstemmed Effects of Dietary Supplementation with Combination of Tributyrin and Essential Oil on Gut Health and Microbiota of Weaned Piglets
title_short Effects of Dietary Supplementation with Combination of Tributyrin and Essential Oil on Gut Health and Microbiota of Weaned Piglets
title_sort effects of dietary supplementation with combination of tributyrin and essential oil on gut health and microbiota of weaned piglets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070613/
https://www.ncbi.nlm.nih.gov/pubmed/31973120
http://dx.doi.org/10.3390/ani10020180
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