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Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study

Lutein and zeaxanthin play important roles in visual functions, but their influence on early visual development is unclear. We related maternal lutein and zeaxanthin concentrations during pregnancy to offspring visual acuity (VA) in 471 mother–child pairs from the Growing Up in Singapore Towards hea...

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Autores principales: Lai, Jun S., Veetil, Vaishnavi O., Lanca, Carla, Lee, Bee Lan, Godfrey, Keith M., Gluckman, Peter D., Shek, Lynette P., Yap, Fabian, Tan, Kok Hian, Chong, Yap Seng, Ong, Choon Nam, Ngo, Cheryl S, Saw, Seang-Mei, Chong, Mary F. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070638/
https://www.ncbi.nlm.nih.gov/pubmed/31972973
http://dx.doi.org/10.3390/nu12020274
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author Lai, Jun S.
Veetil, Vaishnavi O.
Lanca, Carla
Lee, Bee Lan
Godfrey, Keith M.
Gluckman, Peter D.
Shek, Lynette P.
Yap, Fabian
Tan, Kok Hian
Chong, Yap Seng
Ong, Choon Nam
Ngo, Cheryl S
Saw, Seang-Mei
Chong, Mary F. F.
author_facet Lai, Jun S.
Veetil, Vaishnavi O.
Lanca, Carla
Lee, Bee Lan
Godfrey, Keith M.
Gluckman, Peter D.
Shek, Lynette P.
Yap, Fabian
Tan, Kok Hian
Chong, Yap Seng
Ong, Choon Nam
Ngo, Cheryl S
Saw, Seang-Mei
Chong, Mary F. F.
author_sort Lai, Jun S.
collection PubMed
description Lutein and zeaxanthin play important roles in visual functions, but their influence on early visual development is unclear. We related maternal lutein and zeaxanthin concentrations during pregnancy to offspring visual acuity (VA) in 471 mother–child pairs from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. Maternal concentrations of plasma lutein and zeaxanthin were determined at delivery. We measured uncorrected distance of VA in 3-year old children using a LEA Symbols chart; readings were converted to the logarithm of Minimum Angle of Resolution (logMAR), with >0.3 logMAR indicating poor VA. Associations were examined using linear or Poisson regression adjusted for confounders. The median (inter-quartile range) of maternal lutein and zeaxanthin concentrations were 0.13 (0.09, 0.18) and 0.09 (0.07, 0.12) µmol/L, respectively. A total of 126 children had poor VA. The highest tertile of maternal zeaxanthin concentration was associated with 38% lower likelihood of poor VA in children (95% CI: 0.42, 0.93, p-Trends = 0.02). Higher maternal lutein concentrations were associated with a lower likelihood of poor VA in children (RR 0.60 (95% CI: 0.40, 0.88) for middle tertile; RR 0.78 (95% CI: 0.51, 1.19) for highest tertile (p-Quadratic = 0.02)). In conclusion, lutein and zeaxanthin status during pregnancy may influence offspring early visual development; but the results require confirmation with further studies, including more comprehensive measurements of macular functions.
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spelling pubmed-70706382020-03-19 Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study Lai, Jun S. Veetil, Vaishnavi O. Lanca, Carla Lee, Bee Lan Godfrey, Keith M. Gluckman, Peter D. Shek, Lynette P. Yap, Fabian Tan, Kok Hian Chong, Yap Seng Ong, Choon Nam Ngo, Cheryl S Saw, Seang-Mei Chong, Mary F. F. Nutrients Article Lutein and zeaxanthin play important roles in visual functions, but their influence on early visual development is unclear. We related maternal lutein and zeaxanthin concentrations during pregnancy to offspring visual acuity (VA) in 471 mother–child pairs from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. Maternal concentrations of plasma lutein and zeaxanthin were determined at delivery. We measured uncorrected distance of VA in 3-year old children using a LEA Symbols chart; readings were converted to the logarithm of Minimum Angle of Resolution (logMAR), with >0.3 logMAR indicating poor VA. Associations were examined using linear or Poisson regression adjusted for confounders. The median (inter-quartile range) of maternal lutein and zeaxanthin concentrations were 0.13 (0.09, 0.18) and 0.09 (0.07, 0.12) µmol/L, respectively. A total of 126 children had poor VA. The highest tertile of maternal zeaxanthin concentration was associated with 38% lower likelihood of poor VA in children (95% CI: 0.42, 0.93, p-Trends = 0.02). Higher maternal lutein concentrations were associated with a lower likelihood of poor VA in children (RR 0.60 (95% CI: 0.40, 0.88) for middle tertile; RR 0.78 (95% CI: 0.51, 1.19) for highest tertile (p-Quadratic = 0.02)). In conclusion, lutein and zeaxanthin status during pregnancy may influence offspring early visual development; but the results require confirmation with further studies, including more comprehensive measurements of macular functions. MDPI 2020-01-21 /pmc/articles/PMC7070638/ /pubmed/31972973 http://dx.doi.org/10.3390/nu12020274 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lai, Jun S.
Veetil, Vaishnavi O.
Lanca, Carla
Lee, Bee Lan
Godfrey, Keith M.
Gluckman, Peter D.
Shek, Lynette P.
Yap, Fabian
Tan, Kok Hian
Chong, Yap Seng
Ong, Choon Nam
Ngo, Cheryl S
Saw, Seang-Mei
Chong, Mary F. F.
Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study
title Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study
title_full Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study
title_fullStr Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study
title_full_unstemmed Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study
title_short Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study
title_sort maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age: the gusto study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070638/
https://www.ncbi.nlm.nih.gov/pubmed/31972973
http://dx.doi.org/10.3390/nu12020274
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