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Safety, Tolerability, and Pharmacokinetics of the Mineralocorticoid Receptor Modulator AZD9977 in Healthy Men: A Phase I Multiple Ascending Dose Study

Excessive activation of the mineralocorticoid receptor (MR) underlies the pathophysiology of heart failure and chronic kidney disease. Hyperkalemia risk limits the therapeutic use of conventional MR antagonists. AZD9977 is a nonsteroidal, selective MR modulator that may protect nonepithelial tissues...

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Detalles Bibliográficos
Autores principales:	Whittaker, Andrew, Kragh, Åsa M., Hartleib‐Geschwindner, Judith, Albayaty, Muna, Backlund, Anna, Greasley, Peter J., Heijer, Maria, Kjaer, Magnus, Forte, Pablo, Unwin, Robert, Wernevik, Linda, Ericsson, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070793/ https://www.ncbi.nlm.nih.gov/pubmed/31584739 http://dx.doi.org/10.1111/cts.12705

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