Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ‐54175446, a P2X7 Receptor Antagonist

Positron emission tomography (PET) provides useful information in target engagement or receptor occupancy in the brain for central nervous system (CNS) drug development, however, dose selection for human PET studies is challenging and largely empirical. Here, we describe a translational pharmacokine...

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Detalles Bibliográficos
Autores principales: Xu, Yan, Miao, Xin, Ravenstijn, Paulien, Hijzen, Anja, Schmidt, Mark E., Nandy, Partha, Zhou, Honghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070800/
https://www.ncbi.nlm.nih.gov/pubmed/31642608
http://dx.doi.org/10.1111/cts.12711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070800/
https://www.ncbi.nlm.nih.gov/pubmed/31642608
http://dx.doi.org/10.1111/cts.12711

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